Brand  (β version)

PDB ID: 1HLT

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Ligands
Code Name Style Show Link
0G6 D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1HLT   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : THE STRUCTURE OF A NONADECAPEPTIDE OF THE FIFTH EGF DOMAIN OF THROMBOMODULIN COMPLEXED WITH THROMBIN
Release Data : 1994-12-20
Compound :
mol_id molecule chains
1 ALPHA-THROMBIN (SMALL SUBUNIT) L,J
mol_id molecule chains
2 ALPHA-THROMBIN (LARGE SUBUNIT) H,K
mol_id molecule chains
3 Thrombomodulin R
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
3 Homo sapiens  (taxid:9606) Human
Authors : Tulinsky, A., Mathews, I.I.
Keywords : SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 3.0 Å )
Citation :

Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin.

Mathews, I.I.,Padmanabhan, K.P.,Tulinksy, A.  et al.
(1994)  Biochemistry  33 : 13547 - 13552

PubMed: 7947765
DOI: 10.1021/bi00250a006

Alanine-Scanning Mutagenesis of the Epidermal Growth Factor-Like Domains of Human Thrombomodulin Identifies Critical Residues for its Cofactor Activity

Nagashima, M.,Lundh, E.,Leonard, J.C.  et al.
(1993)  J.Biol.Chem.  268 : 2888

Structure of the Hirugen and Hirulog 1 Complexes of Alpha-Thrombin

Skrzypczak-Jankun, E.,Carperos, V.E.,Ravichandran, K.G.  et al.
(1991)  J.Mol.Biol.  221 : 1379

Reaction

Chain : H, K
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : R
UniProt : P07204 (TRBM_HUMAN)
Reaction : -