Het-PDB Navi2 (PDB: 1HK8)

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Ligands
Code	Name	Link
DGT	2'-deoxyguanosine-5'-triphosphate	PoSSuM
MN	Manganese (II) ion	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1HK8

Code :

1HK8 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

STRUCTURAL BASIS FOR ALLOSTERIC SUBSTRATE SPECIFICITY REGULATION IN CLASS III RIBONUCLEOTIDE REDUCTASES: NRDD IN COMPLEX WITH DGTP

Release Data :

2003-03-27

Compound :

mol_id	molecule	chains
1	ANAEROBIC RIBONUCLEOTIDE-TRIPHOSPHATE REDUCTASE	A
	ec: 1.17.4.2 fragment: ACTIVE SITE SUBUNIT, RESIDUES 1-605 mutation: YES other_details: SEQUENCE DETERMINATION\: P.YOUNG, M.OHMAN, M.Q.XU.

Source :

mol_id	organism_scientific	expression_system
1	BACTERIOPHAGE T4 (taxid:10665)	ESCHERICHIA COLI (taxid:562)
	expression_system_strain: JM109(DE3) expression_system_plasmid: PET29T4NRDD(G580A)

Authors :

Larsson, K.-M., Andersson, J., Sjoeberg, B.-M., Nordlund, P., Logan, D.T.

Keywords :

OXIDOREDUCTASE, REDUCTASE, ALLOSTERIC REGULATION, SUBSTRATE SPECIFICITY

Exp. method :

X-RAY DIFFRACTION ( 2.45 Å )

Citation :

A Metal-Binding Site in the Catalytic Subunit of Anaerobic Ribonucleotide Reductase.

Logan, D.T.,Mulliez, E.,Larsson, K.-M. et al.
(2003) Proc.Natl.Acad.Sci.USA 100 : 3826

Structural basis for allosteric substrate specificity regulation in anaerobic ribonucleotide reductases.

Larsson, K.M.,Andersson, J.,Sjoberg, B.M. et al.
(2001) Structure 9 : 739 - 750

Chain :

UniProt :

P07071 (NRDD_BPT4)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a ribonucleoside 5'-triphosphate + formate + H(+) = a 2'- deoxyribonucleoside 5'-triphosphate + CO2 + H2O	1.1.98.6	PubMed:8702830
	-	PubMed:8702830

PDB ID: 1HK8