Het-PDB Navi2 (PDB: 1HJF)

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Ligands
Code	Name		Style	Show	Link
COI	2-oxo-4-methylpentanoic acid				PoSSuM
FE2	Fe (II) ion				PoSSuM

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Download interaction data: 1HJF

Code :

1HJF PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase: The role of arginine-258

Release Data :

2001-06-01

Compound :

mol_id	molecule	chains	synonym
1	DEACETOXYCEPHALOSPORIN C SYNTHASE	A	DAOCS
	mutation: YES other_details: IRON(II) AND ALPHA-KETO-ISOCAPROATE COMPLEX OF MUTANT ENZYME

Source :

mol_id	organism_scientific	expression_system
1	STREPTOMYCES CLAVULIGERUS (taxid:1901)	ESCHERICHIA COLI BL21(DE3) (taxid:469008)
	gene: CEFE, R258Q MUTANT expression_system_vector_type: PLASMID expression_system_plasmid: PET24A other_details: RECOMBINANT ENZYME OF S. CLAVULIGERUS ENZYME. R258Q MUTANT ENZYME

Authors :

Lee, H.J., Lloyd, M.D., Clifton, I.J., Harlos, K., Dubus, A., Baldwin, J.E., Frere, J.M., Schofield, C.J.

Keywords :

OXIDOREDUCTASE, ALTERNATIVE 2-OXOACIDS, CEPHEM ANTIBIOTIC BIOSYNTHESIS, CHEMICAL COSUBSTRATE RESCUE, CO-SUBSTRATE SELECTIVITY, 2- OXOGLUTARATE-DEPENDENT OXYGENASE

Exp. method :

X-RAY DIFFRACTION ( 1.60 Å )

Citation :

Alteration of the 2-Oxoacid Cosubstrate Selectivity in Deacetoxycephalosporin C Synthase: The Role of Arginine-258

Lee, H.J.,Lloyd, M.D.,Harlos, K. et al.
(2001) J.Biol.Chem. 276 : 18290

PubMed: 11279000
DOI: 10.1074/JBC.M100085200

Studies on the Active Site of Deacetoxycephalosporin C Synthase

Lloyd, M.D.,Lee, H.J.,Harlos, K. et al.
(1999) J.Mol.Biol. 287 : 943

PubMed: 10222202
DOI: 10.1006/JMBI.1999.2594

PDB ID: 1HJF

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