Brand  (β version)

PDB ID: 1HIH

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Ligands
Code Name Style Show Link
BME Beta-mercaptoethanol PoSSuM
C20 Acetyl-nh-val-cyclohexyl-ch2[nch2choh]ch2-benzyl-val-nh-acetyl PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1HIH   PDBj   RCSB PDB   PDBe
Header : HYDROLASE (ASPARTIC PROTEINASE)
Title : COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR
Release Data : 1995-07-10
Compound :
mol_id molecule chains
1 HIV-1 PROTEASE A,B
ec: 3.4.23.-
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus 1  (taxid:11676) Escherichia coli  (taxid:562)
cell_line: S2
gene: POL
expression_system_plasmid: PT7Q10H
expression_system_gene: POL
Authors : Priestle, J.P., Gruetter, M.G.
Keywords : ASPARTATE PROTEASE, INHIBITED, HIV, HYDROLASE (ASPARTIC PROTEINASE)
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, a novel pseudosymmetric inhibitor.

Priestle, J.P.,Fassler, A.,Rosel, J.  et al.
(1995)  Structure  3 : 381 - 389

PubMed: 7613867
DOI: 10.1016/S0969-2126(01)00169-1

Novel Pseudosymmetric Inhibitors of HIV-1 Protease

Fassler, A.,Rosel, J.,Tintelnot-Blomley, M.  et al.
(1993)  Bioorg.Med.Chem.Lett.  3 : 2837

Reaction

Chain : A, B
UniProt : P03366 (POL_HV1B1)
Reaction: EC: Evidence:
Physiological Direction:
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. 3.4.23.16 PROSITE-ProRule:PRU00275
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3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 ECO:0000250
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[Reverse transcriptase/ribonuclease H]
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 		3.1.26.13 PubMed:2476069
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[Reverse transcriptase/ribonuclease H]
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 		2.7.7.49 PROSITE- ProRule:PRU00405, PubMed:2476069
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[Reverse transcriptase/ribonuclease H]
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 		2.7.7.7 PROSITE- ProRule:PRU00405, PubMed:2476069
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