Brand  (β version)

PDB ID: 1HDX

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
CXL Cyclohexanol PoSSuM
NAD Nicotinamide-adenine-dinucleotide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1HDX   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE(NAD(A)-CHOH(D))
Title : THREE-DIMENSIONAL STRUCTURES OF THREE HUMAN ALCOHOL DEHYDROGENASE VARIANTS: CORRELATIONS WITH THEIR FUNCTIONAL DIFFERENCES
Release Data : 1994-01-31
Compound :
mol_id molecule chains
1 ALCOHOL DEHYDROGENASE A,B
ec: 1.1.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Hurley, T.D., Amzel, L.M.
Keywords : OXIDOREDUCTASE(NAD(A)-CHOH(D))
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences.

Hurley, T.D.,Bosron, W.F.,Stone, C.L.  et al.
(1994)  J.Mol.Biol.  239 : 415 - 429

PubMed: 8201622
DOI: 10.1006/jmbi.1994.1382

The Structure of Human Beta-1 Alcohol Dehydrogenase: Catalytic Effects of Non-Active Site Substitutions

Hurley, T.D.,Amzel, L.M.
(1991)  Proc.Natl.Acad.Sci.USA  88 : 8149

Reaction

Chain : A, B
UniProt : P00325 (ADH1B_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH 1.1.1.105 PubMed:16787387
left-to-right
all-trans-4-hydroxyretinol + NAD(+) = all-trans-4- hydroxyretinal + H(+) + NADH - PubMed:15369820
left-to-right
all-trans-4-oxoretinol + NAD(+) = all-trans-4-oxoretinal + H(+) + NADH - PubMed:15369820
-