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Ligands
Code Name Style Show Link
0E7 Methyl N-(4-carbamimidamidobutanoyl)-L-phenylalanyl-L-allothreonyl-L-phenylalaninate
Non-standard Residues
Code Name Show
TYS O-sulfo-L-tyrosine
Glycosylation
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Code : 1HDT   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : STRUCTURE OF A RETRO-BINDING PEPTIDE INHIBITOR COMPLEXED WITH HUMAN ALPHA-THROMBIN
Release Data : 1995-10-15
Compound :
mol_id molecule chains
1 ALPHA-THROMBIN L
ec: 3.4.21.5
mol_id molecule chains
2 ALPHA-THROMBIN H
ec: 3.4.21.5
mol_id molecule chains
3 HIRUGEN PEPTIDE P
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
3 Hirudo medicinalis  (taxid:6421) Medicinal leech
Authors : Tabernero, L., Sack, J.
Keywords : SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin.

Tabernero, L.,Chang, C.Y.,Ohringer, S.L.  et al.
(1995)  J.Mol.Biol.  246 : 14 - 20

PubMed: 7853394
DOI: 10.1006/jmbi.1994.0060

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : P
UniProt : P28507 (HIR3A_HIRME)
Reaction : -