Het-PDB Navi2 (PDB: 1HD7)

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Ligands
Code	Name		Style	Show	Link
PB	Lead (II) ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1HD7

Code :

1HD7 PDBj RCSB PDB PDBe

Header :

DNA REPAIR

Title :

A Second Divalent Metal Ion in the Active Site of a New Crystal Form of Human Apurinic/Apyridinimic Endonuclease, Ape1, and its Implications for the Catalytic Mechanism

Release Data :

2001-02-16

Compound :

mol_id	molecule	chains	synonym
1	DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE	A	AP ENDONUCLEASE 1, HAP1, REF1, APE1
	ec: 4.2.99.18

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:469008)
	tissue: ALL cell: ALL organelle: NUCLEUS expression_system_strain: BL21(DE3) expression_system_plasmid: PET11D expression_system_gene: APE1

Authors :

Beernink, P.T., Segelke, B.W., Rupp, B.

Keywords :

DNA REPAIR, ENDONUCLEASE, APE1, HAP1, REF-1

Exp. method :

X-RAY DIFFRACTION ( 1.95 Å )

Citation :

Two Divalent Metal Ions in the Active Site of a New Crystal Form of Human Apurinic/Apyrimidinic Endonuclease, Ape1: Implications for the Catalytic Mechanism

Beernink, P.T.,Segelke, B.W.,Hadi, M.Z. et al.
(2001) J.Mol.Biol. 307 : 1023

PubMed: 11286553
DOI: 10.1006/JMBI.2001.4529

Chain :

UniProt :

P27695 (APEX1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.	3.1.11.2	PubMed:11286553, PubMed:15380100, PubMed:19123919, PubMed:21762700, PubMed:9804799
	-

PDB ID: 1HD7

Hetero Atom Contents

Structure summary

Reaction