Brand  (β version)

PDB ID: 1HD2

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Ligands
Code Name Style Show Link
BEZ Benzoic acid PoSSuM
BR Bromide ion PoSSuM
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Structure summary

Code : 1HD2   PDBj   RCSB PDB   PDBe
Header : ANTIOXIDANT ENZYME
Title : Human peroxiredoxin 5
Release Data : 2001-08-28
Compound :
mol_id molecule chains synonym
1 PEROXIREDOXIN 5 RESIDUES 54-214 A PRDX5, PRXV, AOEB166, PMP20, ARC1
fragment: RESIDUES 54-214
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:1007065)
organ: LUNG
organelle: MITOCHONDRIA-CYTOSOL-PEROXISOME
cellular_location: MITOCHONDRIA-CYTOSOL-PEROXISOME
gene: PRDX5, AOEB166, PMP20, ARC1
expression_system_strain: M15
expression_system_plasmid: PQE-30
Authors : Declercq, J.P., Evrard, C.
Keywords : ANTIOXIDANT ENZYME, PEROXIREDOXIN, THIOREDOXIN PEROXIDASE, THIOREDOXIN FOLD
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

Crystal Structure of Human Peroxiredoxin 5, a Novel Type of Mammalian Peroxiredoxin at 1.5 A Resolution.

Declercq, J.P.,Evrard, C.,Clippe, A.  et al.
(2001)  J.Mol.Biol.  311 : 751

PubMed: 11518528
DOI: 10.1006/JMBI.2001.4853

Cloning and Characterization of Aoeb166, a Novel Mammalian Antioxidant Enzyme of the Peroxiredoxin Family

Knoops, B.,Clippe, A.,Bogard, C.  et al.
(1999)  J.Biol.Chem.  274 : 30451

PubMed: 10521424
DOI: 10.1074/JBC.274.43.30451

Reaction

Chain : A
UniProt : Q9UKX4 (PRDX5_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]- disulfide + an alcohol + H2O 1.11.1.24 PubMed:10751410
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