Brand  (β version)

PDB ID: 1HBT

Hetero Atom Contents

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
ALC 2-amino-3-cyclohexyl-propionic acid
AR0 4-amino-1-{[amino(iminio)methyl]amino}-6-[4-(carboxymethyl)pyridinium-1-yl]-1,2,3,4,6-pentadeoxy-D-erythro-hexitol
DGL D-glutamic acid
ZAL 3-cyclohexyl-D-alanine
Glycosylation
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Modification
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Structure summary

Code : 1HBT   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Human alpha-thrombin complexed with a peptidyl pyridinium methyl ketone containing bivalent inhibitor
Release Data : 1995-07-10
Compound :
mol_id molecule chains synonym
1 ALPHA-THROMBIN (SMALL SUBUNIT) L Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain
ec: 3.4.21.5
mol_id molecule chains synonym
2 ALPHA-THROMBIN (LARGE SUBUNIT) H Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain
ec: 3.4.21.5
mol_id molecule chains
3 P596 Inhibitor peptide I
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
gene: DKFZp470K2111, F2
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
gene: F2
mol_id organism_scientific
3
synthetic: yes
Authors : Rehse, P.H., Cygler, M.
Keywords : SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin.

Rehse, P.H.,Steinmetzer, T.,Li, Y.  et al.
(1995)  Biochemistry  34 : 11537 - 11544

PubMed: 7547884
DOI: 10.1021/bi00036a029

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-