Brand  (β version)

PDB ID: 1HAV

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
Non-standard Residues
Code Name Show
OCS Cysteinesulfonic acid
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1HAV   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : HEPATITIS A VIRUS 3C PROTEINASE
Release Data : 1996-12-23
Compound :
mol_id molecule chains synonym
1 HEPATITIS A VIRUS 3C PROTEINASE A PICORNAIN 3C
ec: 2.7.7.48
mutation: C24S
mol_id molecule chains synonym
2 HEPATITIS A VIRUS 3C PROTEINASE B PICORNAIN 3C
ec: 2.7.7.48
mutation: C24S
Source :
mol_id organism_scientific expression_system
1 Hepatitis A virus  (taxid:12092) Escherichia coli  (taxid:562)
gene: 3C
expression_system_plasmid: PHAV-3CEX
expression_system_gene: 3C
mol_id organism_scientific expression_system
2 Hepatitis A virus  (taxid:12092) Escherichia coli  (taxid:562)
gene: 3C
expression_system_plasmid: PHAV-3CEX
expression_system_gene: 3C
Authors : Bergmann, E.M., James, M.N.G.
Keywords : POLYPROTEIN, COAT PROTEIN, CORE PROTEIN, RNA-DIRECTED RNA POLYMERASE, HYDROLASE, THIOL PROTEASE
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition.

Bergmann, E.M.,Mosimann, S.C.,Chernaia, M.M.  et al.
(1997)  J.Virol.  71 : 2436 - 2448

PubMed: 9032381

Hepatitis a Virus Picornain 3C

Bergmann, E.M.
To be Published 

Picornaviral 3C Cysteine Proteinases Have a Fold Similar to Chymotrypsin-Like Serine Proteinases

Allaire, M.,Chernaia, M.M.,Malcolm, B.A.  et al.
(1994)  Nature  369 : 72

Expression and Characterization of Recombinant Hepatitis a Virus 3C Proteinase

Malcolm, B.A.,Chin, S.M.,Jewell, D.A.  et al.
(1992)  Biochemistry  31 : 3358

Reaction

Chain : B
UniProt : P08617 (POLG_HAVHM)
Reaction: EC: Evidence:
Physiological Direction:
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.48 PROSITE-ProRule:PRU00539, PubMed:8291234
-
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 3.6.1.15 -
-
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. 3.4.22.28 PROSITE-ProRule:PRU01222, PubMed:1850033
-