Brand  (β version)

PDB ID: 1HAP

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Ligands
Code Name Style Show Link
0G6 D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1HAP   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR/DNA
Title : COMPLEX OF HUMAN ALPHA-THROMBIN WITH A 15MER OLIGONUCLEOTIDE GGTTGGTGTGGTTGG (BASED ON X-RAY MODEL OF DNA)
Release Data : 1996-04-03
Compound :
mol_id molecule chains
1 5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3' D
mol_id molecule chains synonym
2 Thrombin light chain L Coagulation factor II
ec: 3.4.21.5
fragment: residues 328-363
mol_id molecule chains synonym
3 Thrombin heavy chain H Coagulation factor II
ec: 3.4.21.5
fragment: residues 364-622
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
3 Homo sapiens  (taxid:9606) Human
Authors : Padmanabhan, K., Tulinsky, A.
Keywords : COAGULATION, QUADRUPLE HELIX, HYDROLASE-HYDROLASE INHIBITOR-DNA COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.800 Å )
Citation :

An ambiguous structure of a DNA 15-mer thrombin complex.

Padmanabhan, K.,Tulinsky, A.
(1996)  Acta Crystallogr.,Sect.D  52 : 272 - 282

PubMed: 15299700
DOI: 10.1107/S0907444995013977

The Structure of Alpha-Thrombin Inhibited by a 15-mer Single-Stranded DNA Aptamer

Padmanabhan, K.,Padmanabhan, K.P.,Ferrara, J.D.  et al.
(1993)  J.Biol.Chem.  268 : 17651 - 17654

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-