Brand  (β version)

PDB ID: 1HAI

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Ligands
Code Name Style Show Link
0G6 D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 1HAI   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/hydrolase inhibitor
Title : THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN
Release Data : 1994-12-20
Compound :
mol_id molecule chains
1 ALPHA-THROMBIN (SMALL SUBUNIT) L
ec: 3.4.21.5
mol_id molecule chains
2 ALPHA-THROMBIN (LARGE SUBUNIT) H
ec: 3.4.21.5
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
organ: PLASMA
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
organ: PLASMA
Authors : Tulinsky, A., Vijayalakshmi, J.
Keywords : SERINE PROTEINASE, HYDROLASE-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.

Vijayalakshmi, J.,Padmanabhan, K.P.,Mann, K.G.  et al.
(1994)  Protein Sci.  3 : 2254 - 2271

PubMed: 7756983

Refined Structure of the Hirudin-Thrombin Complex

Rydel, T.J.,Tulinsky, A.,Bode, W.  et al.
(1991)  J.Mol.Biol.  221 : 583

Structure of the Hirugen and Hirulog 1 Complexes of Alpha-Thrombin

Skrzypczak-Jankun, E.,Carperos, V.E.,Ravichandran, K.G.  et al.
(1991)  J.Mol.Biol.  221 : 1379

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-