Brand  (β version)

PDB ID: 1H70

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Ligands
Code Name Style Show Link
CIR Citrulline PoSSuM
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Glycosylation
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Structure summary

Code : 1H70   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : DDAH FROM PSEUDOMONAS AERUGINOSA. C249S MUTANT COMPLEXED WITH CITRULLINE
Release Data : 2001-08-02
Compound :
mol_id molecule chains
1 NG, NG-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE A
ec: 3.5.3.18
mutation: YES
Source :
mol_id organism_scientific expression_system
1 PSEUDOMONAS AERUGINOSA  (taxid:287) ESCHERICHIA COLI  (taxid:562)
Authors : Murray-Rust, J., Leiper, J., McAlister, M., Phelan, J., Tilley, S., Santamaria, J., Vallance, P., McDonald, N.
Keywords : HYDROLASE, DDAH, NITRIC OXIDE SYNTHASE INHIBITOR
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase.

Murray-Rust, J.,Leiper, J.,McAlister, M.  et al.
(2001)  Nat. Struct. Biol.  8 : 679 - 683

PubMed: 11473257
DOI: 10.1038/90387

Reaction

Chain : A
UniProt : Q9I4E3 (DDAH_PSEAE)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(omega),N(omega)-dimethyl-L-arginine = dimethylamine + L-citrulline 3.5.3.18 PubMed:10510241, PubMed:11473257, PubMed:16634643
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H2O + N(omega)-methyl-L-arginine = L-citrulline + methylamine 3.5.3.18 PubMed:10510241, PubMed:16634643
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