Het-PDB Navi2 (PDB: 1H5U)

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Ligands
Code	Name	Link
CHI	5-chloro-1h-indole-2-carboxylic acid [1-(4-fluorobenzyl)-2-(4-hydroxypiperidin-1yl)-2-oxoethyl]amide	PoSSuM
PLP	Pyridoxal-5'-phosphate	PoSSuM
GLC	Alpha-D-glucopyranose	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1H5U

Code :

1H5U PDBj RCSB PDB PDBe

Header :

GLYCOGEN METABOLISM

Title :

THE 1.76 A RESOLUTION CRYSTAL STRUCTURE OF GLYCOGEN PHOSPHORYLASE B COMPLEXED WITH GLUCOSE AND CP320626, A POTENTIAL ANTIDIABETIC DRUG

Release Data :

2001-06-28

Compound :

mol_id	molecule	chains	synonym
1	GLYCOGEN PHOSPHORYLASE	A	MYOPHOSPHORYLASE
	ec: 2.4.1.1

Source :

mol_id	organism_scientific	organism_common
1	ORYCTOLAGUS CUNICULUS (taxid:9986)	RABBIT
	tissue: MUSCLE

Authors :

Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Archontis, G.

Keywords :

GLYCOGEN METABOLISM, GLYCOGEN PHOSPHORYLASE B, INHIBITION, CENTRAL CAVITY, DRUG BINDING SITE, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 1.76 Å )

Citation :

The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose, and Cp320626, a Potential Antidiabetic Drug

Oikonomakos, N.G.,Zographos, S.E.,Skamnaki, V.T. et al.
(2002) Bioorg.Med.Chem. 10 : 1313

A New Allosteric Site in Glycogen Phosphorylase B as a Target for Drug Interactions

Oikonomakos, N.G.,Skamnaki, V.T.,Tsitsanou, K.E. et al.
(2000) Structure 8 : 575

Chain :

UniProt :

P00489 (PYGM_RABIT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate	2.4.1.1	UniProtKB:P11217
	left-to-right	UniProtKB:P11217

PDB ID: 1H5U