Brand  (β version)

PDB ID: 1H5T

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Ligands
Code Name Style Show Link
DAU 2'deoxy-thymidine-5'-diphospho-alpha-D-glucose PoSSuM
SO4 Sulfate ion PoSSuM
TYD Thymidine-5'-diphosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1H5T   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Thymidylyltransferase complexed with Thymidylyldiphosphate-glucose
Release Data : 2001-11-23
Compound :
mol_id molecule chains synonym
1 Glucose-1-phosphate thymidylyltransferase 1 A,C,D G1P-TT 1,dTDP-glucose pyrophosphorylase 1,dTDP-glucose synthase 1
ec: 2.7.7.24
mol_id molecule chains synonym
2 Glucose-1-phosphate thymidylyltransferase 1 B G1P-TT 1,dTDP-glucose pyrophosphorylase 1,dTDP-glucose synthase 1
ec: 2.7.7.24
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: rfbA, rmlA, rmlA1, b2039, JW2024
mol_id organism_scientific expression_system
2 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: rfbA, rmlA, rmlA1, b2039, JW2024
Authors : Rosano, C., Zuccotti, S., Bolognesi, M.
Keywords : TRANSFERASE, PYROPHOSPHATASE, NUCLEOTIDE SUGAR METHABOLISM
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

Kinetic and Crystallographic Analyses Support a Sequential-Ordered Bi Bi Catalytic Mechanism for Escherichia Coli Glucose-1-Phosphate Thymidylyltransferase

Zuccotti, S.,Zanardi, D.,Rosano, C.  et al.
(2001)  J.Mol.Biol.  313 : 831

PubMed: 11697907
DOI: 10.1006/JMBI.2001.5073

Reaction

Chain : B
UniProt : P37744 (RMLA1_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose 2.7.7.24 PubMed:11697907
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