Het-PDB Navi2 (PDB: 1H2Z)

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Ligands
Code	Name	Link
GLY	Glycine	PoSSuM
GOL	Glycerol	PoSSuM
PRO	Proline	PoSSuM
SIN	Succinic acid	PoSSuM

Non-standard Residues
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Download interaction data: 1H2Z

Code :

1H2Z PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN, S554A MUTANT WITH BOUND PEPTIDE LIGAND SUC-GLY-PRO

Release Data :

2002-11-11

Compound :

mol_id	molecule	chains	synonym
1	PROLYL ENDOPEPTIDASE	A	POST-PROLINE CLEAVING ENZYME, PE
	ec: 3.4.21.26 mutation: YES other_details: ENGINEERED MUTATION SER 554 ALA

Source :

mol_id	organism_scientific	organism_common	expression_system
1	SUS SCROFA (taxid:9823)	PIG	ESCHERICHIA COLI (taxid:562)
	tissue: BRAIN

Authors :

Rea, D., Fulop, V.

Keywords :

HYDROLASE, PROLYL OLIGOPEPTIDASE, AMNESIA, ALPHA/ BETA-HYDROLASE, BETA-PROPELLER, SERINE PROTEASE

Exp. method :

X-RAY DIFFRACTION ( 1.65 Å )

Citation :

Electrostatic Effects and Binding Determinants in the Catalysis of Prolyl Oligopeptidase: Site Specific Mutagenesis at the Oxyanion Binding Site

Szeltner, Z.,Rea, D.,Renner, V. et al.
(2002) J.Biol.Chem. 277 : 42613

PubMed: 12202494
DOI: 10.1074/JBC.M208043200

Structures of Prolyl Oligopeptidase Substrate/ Inhibitor Complexes. Use of Inhibitor Binding for Titration of the Catalytic Histidine Residue

Fulop, V.,Szeltner, Z.,Renner, V. et al.
(2001) J.Biol.Chem. 276 : 1262

PubMed: 11031266
DOI: 10.1074/JBC.M007003200

Catalysis of Serine Oligopeptidases is Controlled by a Gating Filter Mechanism

Fulop, V.,Szeltner, Z.,Polgar, L.
(2000) Embo Rep. 1 : 277

PubMed: 11256612
DOI: 10.1093/EMBO-REPORTS/KVD048

Prolyl Oligopeptidase: An Unusual Beta-Propeller Domain Regulates Proteolysis

Fulop, V.,Bocskei, Z.,Polgar, L.
(1998) Cell(Cambridge,Mass.) 94 : 161

PubMed: 9695945
DOI: 10.1016/S0092-8674(00)81416-6

Chain :

UniProt :

P23687 (PPCE_PIG)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Hydrolysis of Pro-\|-Xaa >> Ala-\|-Xaa in oligopeptides.	3.4.21.26	-
Hydrolysis of Pro-\|-Xaa >> Ala-\|-Xaa in oligopeptides.	-	-

PDB ID: 1H2Z

Hetero Atom Contents

Structure summary

Reaction