Het-PDB Navi2 (PDB: 1H1P)

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Ligands
Code	Name		Style	Show	Link
CMG	6-O-cyclohexylmethyl guanine				PoSSuM

Non-standard Residues
Code	Name	Show
TPO	Phosphothreonine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 1H1P

Code :

1H1P PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU2058

Release Data :

2002-09-19

Compound :

mol_id	molecule	chains	synonym
1	CELL DIVISION PROTEIN KINASE 2	A,C	CYCLIN-DEPENDENT KINASE 2, P33 PROTEIN KINASE
	ec: 2.7.1.- other_details: PHOSPHORYLATED ON THR160

mol_id	molecule	chains	synonym
2	CYCLIN A2	B,D	CYCLIN A, CYCLIN A3

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:562)

mol_id	organism_scientific	organism_common	expression_system
2	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:562)

Authors :

Davies, T.G., Noble, M.E.M., Endicott, J.A., Johnson, L.N.

Keywords :

KINASE, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, CELL CYCLE, CELL DIVISION, MITOSIS, PHOSPHORYLATION

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

Structure-Based Design of a Potent Purine-Based Cyclin-Dependent Kinase Inhibitor

Davies, T.G.,Bentley, J.,Arris, C.E. et al.
(2002) Nat.Struct.Biol. 9 : 745

Chain :

A, C

UniProt :

P24941 (CDK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.22	PubMed:1396589, PubMed:28666995, PubMed:9030781
	-	PubMed:1396589, PubMed:28666995, PubMed:9030781
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.22	PubMed:1396589, PubMed:28666995, PubMed:9030781
	-	PubMed:1396589, PubMed:28666995, PubMed:9030781

PDB ID: 1H1P