Brand  (β version)

PDB ID: 1H19

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Ligands
Code Name Style Show Link
ACY Acetic acid PoSSuM
IMD Imidazole PoSSuM
YB Ytterbium (III) ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1H19   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : STRUCTURE OF [E271Q]LEUKOTRIENE A4 HYDROLASE
Release Data : 2002-08-08
Compound :
mol_id molecule chains synonym
1 LEUKOTRIENE A-4 HYDROLASE A LTA-4 HYDROLASE, LEUKOTRIENE A(4) HYDROLASE
ec: 3.3.2.6
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
expression_system_strain: JM101
expression_system_plasmid: PT3-MB4
Authors : Rudberg, P.C., Tholander, F., Thunnissen, M.M.G.M., Haeggstrom, J.Z.
Keywords : HYDROLASE, ALPHA-BETA PROTEIN, LEUKOTRIENE BIOSYNTHESIS, METALLOPROTEASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Leukotriene A4 Hydrolase/Aminopeptidase, Glutamate 271 is a Catalyticresidue with Specific Roles in Two Distinct Enzyme Mechanisms

Rudberg, P.C.,Tholander, F.,Thunnissen, M.M.G.M.  et al.
(2002)  J.Biol.Chem.  277 : 1398

PubMed: 11675384
DOI: 10.1074/JBC.M106577200

Reaction

Chain : A
UniProt : P09960 (LKHA4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + leukotriene A4 = leukotriene B4 3.3.2.6 PubMed:11675384, PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:24591641, PubMed:6490615, PubMed:7667299, PubMed:9395533
left-to-right PubMed:11917124
(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)- eicosapentaenoate + H2O = resolvin E1 - PubMed:21206090
left-to-right
(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)- eicosapentaenoate + H2O = 18S-resolvin E1 - PubMed:21206090
left-to-right
Release of the N-terminal residue from a tripeptide. 3.4.11.4 PubMed:11675384, PubMed:11917124, PubMed:20813919, PubMed:24591641, PubMed:9395533
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