Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
YB Ytterbium (III) ion
ZN Zinc ion
ACY Acetic acid
IMD Imidazole
Code : 1H19
Header : HYDROLASE
Title : STRUCTURE OF [E271Q]LEUKOTRIENE A4 HYDROLASE
Release Data : 2002-08-08
Compound :
mol_id molecule chains synonym
1 LEUKOTRIENE A-4 HYDROLASE A LTA-4 HYDROLASE, LEUKOTRIENE A(4) HYDROLASE
ec: 3.3.2.6
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
expression_system_strain: JM101
expression_system_plasmid: PT3-MB4
Authors : Rudberg, P.C., Tholander, F., Thunnissen, M.M.G.M., Haeggstrom, J.Z.
Keywords : HYDROLASE, ALPHA-BETA PROTEIN, LEUKOTRIENE BIOSYNTHESIS, METALLOPROTEASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Leukotriene A4 Hydrolase/Aminopeptidase, Glutamate 271 is a Catalyticresidue with Specific Roles in Two Distinct Enzyme Mechanisms

Rudberg, P.C.,Tholander, F.,Thunnissen, M.M.G.M.  et al.
(2002)  J.Biol.Chem.  277 : 1398

PubMed: 11675384
DOI: 10.1074/JBC.M106577200

Chain : A
UniProt : P09960 (LKHA4_HUMAN)
Reaction : (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa- 7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12- dihydroxyicosa-6,8,10,14-tetraenoate.