PDB ID: 1H01
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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FAL | (2r)-1-[4-({4-[(2,5-dichlorophenyl)amino]pyrimidin-2-yl}amino)phenoxy]-3-(dimethylamino)propan-2-ol | PoSSuM | |||
FBL | (2s)-1-[4-({4-[(2,5-dichlorophenyl)amino]pyrimidin-2-yl}amino)phenoxy]-3-(dimethylamino)propan-2-ol | PoSSuM | |||
GOL | Glycerol | PoSSuM |
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KCX | Lysine nz-carboxylic acid |
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Download interaction data: 1H01
Structure summary
Code : | 1H01 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor | ||||||||||||
Release Data : | 2003-07-11 | ||||||||||||
Compound : |
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Source : |
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Authors : | Breault, G.A., Ellston, R.P.A., Green, S., James, S.R., Jewsbury, P.J., Midgley, C.J., Minshull, C.A., Pauptit, R.A., Tucker, J.A., Pease, J.E. | ||||||||||||
Keywords : | SERINE/THREONINE-PROTEIN KINASE, MITOSIS, TRANSFERASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.79 Å ) | ||||||||||||
Citation : |
Cyclin-Dependent Kinase 4 Inhibitors as a Treatment for Cancer. Part 1: Identification and Optimisation of Substituted 4,6-Bis Anilino Pyrimidines
Beattie, J.F.,Breault, G.A.,Ellston, R.P.A.
et al.
PubMed: 12941311 High-Resolution Crystal Structures of Human Cyclin-Dependent Kinase 2 with and without ATP: Bound Waters and Natural Ligand as a Guide for Inhibitor Design
Schulze-Gahmen, U.,De Bondt, H.,Kim, S.-H.
PubMed: 8917641 |
Reaction
Chain : | A | ||||||||||||
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UniProt : | P24941 (CDK2_HUMAN) | ||||||||||||
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