PDB ID: 1H00
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Code | Name | Style | Show | Link | |
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FAP | (2s)-1-[4-({6-[(2,6-difluorophenyl)amino]pyrimidin-4-yl}amino)phenoxy]-3-(dimethylamino)propan-2-ol | PoSSuM | |||
FCP | (2r)-1-[4-({6-[(2,6-difluorophenyl)amino]pyrimidin-4-yl}amino)phenoxy]-3-(dimethylamino)propan-2-ol | PoSSuM |
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ACE | Acetyl group |
Download interaction data: 1H00
Structure summary
Code : | 1H00 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor | ||||||||||||
Release Data : | 2003-07-11 | ||||||||||||
Compound : |
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Source : |
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Authors : | Beattie, J.F., Breault, G.A., Ellston, R.P.A., Green, S., Jewsbury, P.J., Midgley, C.J., Naven, R.T., Minshull, C.A., Pauptit, R.A., Tucker, J.A., Pease, J.E. | ||||||||||||
Keywords : | SERINE/THREONINE-PROTEIN KINASE, MITOSIS, TRANSFERASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.60 Å ) | ||||||||||||
Citation : |
Cyclin-Dependent Kinase 4 Inhibitors as a Treatment for Cancer. Part 1: Identification and Optimisation of Substituted 4,6-Bis Anilino Pyrimidines
Beattie, J.F.,Breault, G.A.,Ellston, R.P.A.
et al.
PubMed: 12941311 High-Resolution Crystal Structures of Human Cyclin-Dependent Kinase 2 with and without ATP: Bound Waters and Natural Ligand as a Guide for Inhibitor Design
Schulze-Gahmen, U.,De Bondt, H.,Kim, S.-H.
PubMed: 8917641 |
Reaction
Chain : | A | ||||||||||||
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UniProt : | P24941 (CDK2_HUMAN) | ||||||||||||
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