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Ligands
Code Name Style Show Link
ATP Adenosine-5'-triphosphate
FUM Fumaric acid
MN Manganese (II) ion
OXL Oxalate ion
Non-standard Residues
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Glycosylation
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Code : 1GZ3   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate
Release Data : 2003-05-22
Compound :
mol_id molecule chains synonym
1 NAD-dependent malic enzyme, mitochondrial A,B,C,D NAD-ME,Malic enzyme 2
ec: 1.1.1.38
fragment: RESIDUES 20-573
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
organelle: MITOCHONDRION
gene: ME2
Authors : Yang, Z., Lanks, C.W., Tong, L.
Keywords : ALLOSTERIC REGULATION, ENERGY METABOLISM, KINETICS, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

Molecular Mechanism for the Regulation of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme by ATP and Fumarate

Yang, Z.,Lanks, C.W.,Tong, L.
(2002)  Structure  10 : 951 - 960

PubMed: 12121650
DOI: 10.1016/S0969-2126(02)00788-8

Chain : A, B, C, D
UniProt : P23368 (MAOM_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(S)-malate + NAD(+) = CO2 + NADH + pyruvate 1.1.1.38 PubMed:12121650, PubMed:1993674
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H(+) + oxaloacetate = CO2 + pyruvate 1.1.1.38 PubMed:12121650, PubMed:1993674
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