Brand  (β version)

PDB ID: 1GX1

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Ligands
Code Name Style Show Link
CDP Cytidine-5'-diphosphate PoSSuM
MN Manganese (II) ion PoSSuM
SO4 Sulfate ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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MSE Selenomethionine
Glycosylation
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Structure summary

Code : 1GX1   PDBj   RCSB PDB   PDBe
Header : SYNTHASE
Title : Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase
Release Data : 2002-04-03
Compound :
mol_id molecule chains synonym
1 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE A,B,C MECPS, MECDP-SYNTHASE
ec: 4.6.1.12
Source :
mol_id organism_scientific expression_system
1 ESCHERICHIA COLI  (taxid:511693) ESCHERICHIA COLI  (taxid:562)
strain: BL21
expression_system_plasmid: PET15B
other_details: SYNTHETIC GENE
Authors : Kemp, L.E., Bond, C.S., Hunter, W.N.
Keywords : SYNTHASE, ISOPRENOID, LYASE, ISOPRENE BIOSYNTHESIS
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Structure of 2C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase: An Essential Enzyme for Isoprenoid Biosynthesis and Target for Antimicrobial Drug Development

Kemp, L.E.,Bond, C.S.,Hunter, W.N.
(2002)  Proc.Natl.Acad.Sci.USA  99 : 6591

PubMed: 11997478
DOI: 10.1073/PNAS.102679799

Reaction

Chain : A, B, C
UniProt : P36663 (ISPF_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D- erythritol 2,4-cyclic diphosphate + CMP 4.6.1.12 HAMAP-Rule:MF_00107, PubMed:10694574, PubMed:22839733
-
4-CDP-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 3,4- cyclophosphate + CMP + H(+) - PubMed:10694574
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Cofactor: Evidence: Note:
a divalent metal cation ECO:0000255 | HAMAP-Rule:MF_00107
ECO:0000269 | PubMed:10694574
ECO:0000269 | PubMed:11786530
ECO:0000269 | PubMed:11829504
ECO:0000269 | PubMed:11997478
ECO:0000269 | PubMed:15608374
ECO:0000269 | PubMed:16392111
ECO:0000269 | PubMed:16511114
ECO:0000269 | PubMed:19320487
Binds 1 divalent metal cation per subunit.