Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
YB Ytterbium (III) ion
ZN Zinc ion
ACT Acetate ion
BES 2-(3-amino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoic acid
IMD Imidazole
Code : 1GW6
Header : HYDROLASE
Title : STRUCTURE OF LEUKOTRIENE A4 HYDROLASE D375N MUTANT
Release Data : 2003-03-06
Compound :
mol_id molecule chains synonym
1 LEUKOTRIENE A-4 HYDROLASE A LTA-4 HYDROLASE, LEUKOTRIENE A(4)HYDROLASE, LTA-4 HYDROLASE, LEUKOTRIENE A(4) HYDROLASE
ec: 3.3.2.6
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
expression_system_plasmid: PT3-MB4
Authors : Rudberg, P.C., Tholander, F., Thunnissen, M.M.G.M., Samuelsson, B., Haeggstrom, J.Z.
Keywords : HYDROLASE, MUTAGENESIS STUDIES, ALPHA-BETA PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Leukotriene A4 Hydrolase: Selective Abrogation of Leukotriene B4 Formation by Mutation of Aspartic Acid 375

Rudberg, P.C.,Tholander, F.,Thunnissen, M.M.G.M.  et al.
(2002)  Proc.Natl.Acad.Sci.USA  99 : 4215

PubMed: 11917124
DOI: 10.1073/PNAS.072090099

Crystal Structure of Human Leukotriene A4 Hydrolase, a Bifunctional Enzyme in Inflammation

Thunnissen, M.M.G.M.,Nordlund, P.N.,Haeggstrom, J.Z.
(2001)  Nat.Struct.Biol.  8 : 131

PubMed: 11175901
DOI: 10.1038/84117

Chain : A
UniProt : P09960 (LKHA4_HUMAN)
Reaction : (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa- 7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12- dihydroxyicosa-6,8,10,14-tetraenoate.