Brand  (β version)

PDB ID: 1GW6

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
BES 2-(3-amino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoic acid PoSSuM
IMD Imidazole PoSSuM
YB Ytterbium (III) ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1GW6   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : STRUCTURE OF LEUKOTRIENE A4 HYDROLASE D375N MUTANT
Release Data : 2003-03-06
Compound :
mol_id molecule chains synonym
1 LEUKOTRIENE A-4 HYDROLASE A LTA-4 HYDROLASE, LEUKOTRIENE A(4)HYDROLASE, LTA-4 HYDROLASE, LEUKOTRIENE A(4) HYDROLASE
ec: 3.3.2.6
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
expression_system_plasmid: PT3-MB4
Authors : Rudberg, P.C., Tholander, F., Thunnissen, M.M.G.M., Samuelsson, B., Haeggstrom, J.Z.
Keywords : HYDROLASE, MUTAGENESIS STUDIES, ALPHA-BETA PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Leukotriene A4 Hydrolase: Selective Abrogation of Leukotriene B4 Formation by Mutation of Aspartic Acid 375

Rudberg, P.C.,Tholander, F.,Thunnissen, M.M.G.M.  et al.
(2002)  Proc.Natl.Acad.Sci.USA  99 : 4215

PubMed: 11917124
DOI: 10.1073/PNAS.072090099

Crystal Structure of Human Leukotriene A4 Hydrolase, a Bifunctional Enzyme in Inflammation

Thunnissen, M.M.G.M.,Nordlund, P.N.,Haeggstrom, J.Z.
(2001)  Nat.Struct.Biol.  8 : 131

PubMed: 11175901
DOI: 10.1038/84117

Reaction

Chain : A
UniProt : P09960 (LKHA4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + leukotriene A4 = leukotriene B4 3.3.2.6 PubMed:11675384, PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:24591641, PubMed:6490615, PubMed:7667299, PubMed:9395533
left-to-right PubMed:11917124
(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)- eicosapentaenoate + H2O = resolvin E1 - PubMed:21206090
left-to-right
(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)- eicosapentaenoate + H2O = 18S-resolvin E1 - PubMed:21206090
left-to-right
Release of the N-terminal residue from a tripeptide. 3.4.11.4 PubMed:11675384, PubMed:11917124, PubMed:20813919, PubMed:24591641, PubMed:9395533
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