Brand  (β version)

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Modified Residues
Code Name Link
GGL Gamma-L-glutamic acid
ICY S-(2-iodobenzyl)-L-cysteine
Code : 1GUL   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : HUMAN GLUTATHIONE TRANSFERASE A4-4 COMPLEX WITH IODOBENZYL GLUTATHIONE
Release Data : 1999-01-27
Compound :
mol_id molecule chains synonym
1 GLUTATHIONE TRANSFERASE A4-4 A,B,C,D,E,F,G,H GLUTATHIONE S-TRANSFERASE, GST
ec: 2.5.1.18
mol_id molecule chains
2 S-(2-iodobenzyl) glutathione I,J,K,L,M,N,O,P
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
organ: BRAIN
tissue: SUBSTANTIA NIGRA
expression_system_strain: JM109
expression_system_cellular_location: CYTOPLASM
expression_system_vector: PKK-D
mol_id organism_scientific
2
synthetic: yes
Authors : Bruns, C.M., Hubatsch, I., Ridderstrom, M., Mannervik, B., Tainer, J.A.
Keywords : OXIDATIVE STRESS, ALKENAL DEGRADATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.70 Å )
Citation :

Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products

Bruns, C.M.,Hubatsch, I.,Ridderstrom, M.  et al.
(1999)  J.Mol.Biol.  288 : 427 - 439

PubMed: 10329152
DOI: 10.1006/jmbi.1999.2697

Human Glutathione Transferase A4-4: An Alpha Class Enzyme with High Catalytic Efficiency in the Conjugation of 4-Hydroxynonenal and Other Genotoxic Products of Lipid Peroxidation

Hubatsch, I.,Ridderstrom, M.,Mannervik, B.
(1998)  Biochem.J.  330 : 175

Chain : A, B, C, D, E, F, G, H
UniProt : O15217 (GSTA4_HUMAN)
Reaction : RX + glutathione = HX + R-S-glutathione.