Brand  (β version)

PDB ID: 1GTK

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Ligands
Code Name Style Show Link
DPM 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1h-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1h-pyrrol-3-yl]propanoic acid PoSSuM
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Structure summary

Code : 1GTK   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Time-resolved and static-ensemble structural chemistry of hydroxymethylbilane synthase
Release Data : 2003-01-16
Compound :
mol_id molecule chains synonym
1 PORPHOBILINOGEN DEAMINASE A HYDROXYMETHYLBILANE SYNTHASE, PBG, HMBS, HYDROXYMETHYLBILANE SYNTHASE, PRE-UROPORPHYRINOGEN SYNTHASE
ec: 2.5.1.61
fragment: THREE DOMAINS
other_details: CONTAINS A DIPYRROMETHANE COFACTOR LINKED TO CYSTEINE 242
Source :
mol_id organism_scientific expression_system
1 ESCHERICHIA COLI  (taxid:562) ESCHERICHIA COLI  (taxid:562)
Authors : Helliwell, J.R., Nieh, Y.P., Raftery, J., Cassetta, A., Habash, J., Carr, P.D., Ursby, T., Wulff, M., Thompson, A.W., Niemann, A.C., Haedener, A.
Keywords : TRANSFERASE, BIOSYNTHESIS OF LINEAR TETRAPYRROLE, ALL ALPHA/BETA
Exp. method : X-RAY DIFFRACTION ( 1.66 Å )
Citation :

Time-Resolved and Static-Ensemble Structural Chemistry of Hydroxymethylbilane Synthase

Helliwell, J.R.,Nieh, Y.P.,Habash, J.  et al.
(2003)  Faraday Discuss.  122 : 131

PubMed: 12555854
DOI: 10.1039/B201331B

Time-Resolved Structures of Hydroxymethylbilane Synthase (Lys59Gln Mutant) as It is Loaded with Substrate in the Crystal Determined by Laue Diffraction

Helliwell, J.R.,Nieh, Y.P.,Raftery, J.  et al.
(1998)  J.Chem.Soc.,Faraday Trans.  94 : 2615

DOI: 10.1039/A802217H

Reaction

Chain : A
UniProt : P06983 (HEM3_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+) 2.5.1.61 PubMed:3052434
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