PDB ID: 1GSZ
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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C8E | (hydroxyethyloxy)tri(ethyloxy)octane | PoSSuM | |||
R71 | [4-({6-[allyl(methyl)amino]hexyl}oxy)-2-fluorophenyl](4-bromophenyl)methanone | PoSSuM |
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Download interaction data: 1GSZ
Structure summary
Code : | 1GSZ PDBj RCSB PDB PDBe | ||||||||||||
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Header : | ISOMERASE | ||||||||||||
Title : | Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071 | ||||||||||||
Release Data : | 2003-01-16 | ||||||||||||
Compound : |
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Authors : | Lenhart, A., Weihofen, W.A., Pleschke, A.E.W., Schulz, G.E. | ||||||||||||
Keywords : | ISOMERASE, CHOLESTEROL BIOSYNTHESIS, INHIBITOR OXIDOSQUALENE CYCLASE, MONOTOPIC MEMBRANE PROTEIN | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.8 Å ) | ||||||||||||
Citation : |
Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071
Lenhart, A.,Weihofen, W.A.,Pleschke, A.E.W.
et al.
PubMed: 12031670 The Structure of the Membrane Protein Squalene-Hopene Cyclase at 2.0 A Resolution
Wendt, K.U.,Lenhart, A.,Schulz, G.E.
PubMed: 9931258 Structure and Function of a Squalene Cyclase
Wendt, K.U.,Poralla, K.,Schulz, G.E.
PubMed: 9295270 Crystallization and Preliminary X-Ray Crystallographic Analysis of Squalene-Hopene Cyclase from Alicyclobacillus Acidocaldarius
Wendt, K.U.,Feil, C.,Lenhart, A.
et al.
PubMed: 9070455 Ro48-8071, a New 2,3-Oxidosqualene:Lanosterol Cyclase Inhibitor Lowering Plasma Cholesterol in Hamsters, Squirrel Monkeys, and Minipigs: Comparison to Simvastatin
Morand, O.H.,Aebi, J.D.,Dehmlow, H.
et al.
PubMed: 9162756 |
Reaction
Chain : | A, B, C | ||||||||||||
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UniProt : | P33247 (SQHC_ALIAD) | ||||||||||||
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