Brand  (β version)

PDB ID: 1GQC

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Ligands
Code Name Style Show Link
C5P Cytidine-5'-monophosphate PoSSuM
CMK Cytidine 5'-monophosphate 3-deoxy-beta-D-gulo-oct-2-ulo-pyranosonic acid PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1GQC   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : THE STRUCTURE OF CMP:2-KETO-3-DEOXY-MANNO-OCTONIC ACID SYNTHETASE COMPLEXED WITH CMP-Kdo at 100K
Release Data : 2002-02-11
Compound :
mol_id molecule chains synonym
1 3-DEOXY-MANNO-OCTULOSONATE CYTIDYLYLTRANSFERASE A,B CMP-KDO SYNTHETASE, CMP-2-KETO-3-DEOXYOCTULOSONIC ACID SYNTHETASE, CKS
ec: 2.7.7.38
Source :
mol_id organism_scientific expression_system
1 ESCHERICHIA COLI  (taxid:562) ESCHERICHIA COLI  (taxid:562)
strain: K5
Authors : Jelakovic, S., Schulz, G.E.
Keywords : TRANSFERASE, NUCLEOTIDYLTRANSFERASE, CMP-KDO SYNTHETASE, NUCLEOSIDE MONOPHOSPHATE GLYCOSIDES, LIPOPOLYSACCHARIDE BIOSYNTHESIS, SUGAR-ACTIVATING ENZYMES
Exp. method : X-RAY DIFFRACTION ( 2.6 Å )
Citation :

Catalytic Mechanism of Cmp:2-Keto-3-Deoxy-Manno-Octonic Acid Synthetase as Derived from Complexes with Reaction Educt and Product.

Jelakovic, S.,Schulz, G.E.
(2002)  Biochemistry  41 : 1174

PubMed: 11802716
DOI: 10.1021/BI0119060

The Structure of Cmp:2-Keto-3-Deoxy-Manno-Octonic Acid Synthetase and of its Complexes with Substrates and Substrate Analogs

Jelakovic, S.,Schulz, G.E.
(2001)  J.Mol.Biol.  312 : 143

PubMed: 11545592
DOI: 10.1006/JMBI.2001.4948

The Three-Dimensional Structure of Capsule-Specific Cmp:2-Keto-3-Deoxy-Manno-Octonic Acid Synthetase from Escherichia Coli

Jelakovic, S.,Jann, K.,Schulz, G.E.
(1996)  FEBS Lett.  391 : 157

PubMed: 8706906
DOI: 10.1016/0014-5793(96)00724-7

Reaction

Chain : A, B
UniProt : P42216 (KPSU5_ECOLX)
Reaction: EC: Evidence:
Physiological Direction:
3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy- beta-D-manno-octulosonate + diphosphate 2.7.7.38 HAMAP-Rule:MF_00057
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