Brand  (β version)

PDB ID: 1GP6

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Ligands
Code Name Style Show Link
DH2 (2s,3s)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4h-chromen-4-one PoSSuM
FE2 Fe (II) ion PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
QUE 3,5,7,3',4'-pentahydroxyflavone PoSSuM
SIN Succinic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1GP6   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Anthocyanidin synthase from Arabidopsis thaliana complexed with trans-dihydroquercetin (with 30 min exposure to O2)
Release Data : 2002-02-21
Compound :
mol_id molecule chains synonym
1 LEUCOANTHOCYANIDIN DIOXYGENASE A LDOX, LEUCOCYANIDIN OXYGENASE, ANTHOCYANIDIN SYNTHASE, ANS, LEUCOANTHOCYANIDIN HYDROXYLASE, PROTEIN TANNIN DEFICIENT SEED 4, TDS4, PROTEIN TRANSPARENT TESTA 11, TT11, PROTEIN TRANSPARENT TESTA 17, TT17, PROTEIN TRANSPARENT TESTA 18, TT18
ec: 1.14.11.19
Source :
mol_id organism_scientific organism_common expression_system
1 ARABIDOPSIS THALIANA  (taxid:3702) MOUSE-EAR CRESS ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET-24A
Authors : Wilmouth, R.C., Turnbull, J.J., Welford, R.W.D., Clifton, I.J., Prescott, A.G., Schofield, C.J.
Keywords : OXIDOREDUCTASE, OXYGENASE, 2-OXOGLUTARATE DEPENDENT DIOXYGENASE, FLAVONOID BIOSYNTHESIS
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

Structure and Mechanism of Anthocyanidin Synthase from Arabidopsis Thaliana.

Wilmouth, R.C.,Turnbull, J.J.,Welford, R.W.D.  et al.
(2002)  Structure  10 : 93

PubMed: 11796114
DOI: 10.1016/S0969-2126(01)00695-5

Are Anthocyanidins the Immediate Products of Anthocyanidin Synthase?

Turnbull, J.J.,Sobey, W.J.,Aplin, R.T.  et al.
(2000)  Chem.Commun.  : 2473

DOI: 10.1039/B007594I

Purification, Crystallization and Preliminary X-Ray Diffraction of Anthocyanidin Synthase from Arabidopsis Thaliana

Turnbull, J.J.,Prescott, A.G.,Schofield, C.J.  et al.
(2001)  Acta Crystallogr.,Sect.D  D57 : 425

PubMed: 11223521
DOI: 10.1107/S0907444900019818

Direct Evidence for Anthocyanidin Synthase as a 2-Oxoglutarate-Dependent Oxygenase: Molecular Cloning and Functional Expression of Cdna from a Red Forma of Perilla Frutescens

Saito, K.,Kobayashi, M.,Gong, Z.  et al.
(1999)  Plant J.  17 : 181

PubMed: 10074715
DOI: 10.1046/J.1365-313X.1999.00365.X

Reaction

Chain : A
UniProt : Q96323 (LDOX_ARATH)
Reaction: EC: Evidence:
Physiological Direction:
2-oxoglutarate + a (2R,3S,4S)-leucoanthocyanidin + O2 = a 4-H- anthocyanidin with a 3-hydroxy group + CO2 + 2 H2O + succinate 1.14.20.4 PubMed:16153644
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(2R,3S,4S)-3,4-leucopelargonidin + 2-oxoglutarate + O2 = (4S)- 2,3-dehydroleucopelargonidin + CO2 + H(+) + H2O + succinate 1.14.20.4 PubMed:16153644
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(2R,3S,4S)-leucocyanidin + 2-oxoglutarate + O2 = (4S)-2,3- dehydroleucocyanidin + CO2 + H(+) + H2O + succinate 1.14.20.4 PubMed:16153644
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