Brand  (β version)

PDB ID: 1GOE

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
AIB Alpha-aminoisobutyric acid
DPN D-phenylalanine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
NH2 Amino group

Structure summary

Code : 1GOE   PDBj   RCSB PDB   PDBe
Header : HORMONE
Title : Monitoring the structural Consequences of Phe12-->D-Phe12 and Leu15-->Aib15 substitution in H/R Corticotropin Releasing Hormone: Implications for Design of CRH antagonists.
Release Data : 2001-10-31
Compound :
mol_id molecule chains
1 CORTICOTROPIN RELEASING HORMONE A
mutation: YES
other_details: SYNTHETIC ANALOGUE WITH ISOLEUCINE-AMIDE C-TERMINUS
Source :
mol_id organism_scientific organism_common
1 HOMO SAPIENS  (taxid:9606) HUMAN
synthetic: yes
other_details: SYNTHETIC ANALOGUE SYNTHESIZED THROUGH SOLID PHASE SYNTHESIS USING FMOC/TBU SYNTHETIC PROTOCOLS. NATIVE PHE12 AND LEU15 HAS BEEN SUBSTITUTED BY D-PHE AND ALPHA-AMINOISOBUTYRIC ACID
Authors : Spyroulias, G.A., Papazacharias, S., Pairas, G., Cordopatis, P.
Keywords : HORMONE, CORTICOTROPIN RELEASING HORMONE, SYNTHETIC ANALOGUES, SOLID PHASE SYNTHESIS, SOLUTIONS STRUCTURE
Exp. method : SOLUTION NMR
Citation :

Monitoring the Structural Consequences of Phe12-->D-Phe and Leu15-->Aib Substitution in Human/Rat Corticotropin Releasing Hormone

Spyroulias, G.A.,Papazacharias, S.,Pairas, G.  et al.
(2002)  Eur.J.Biochem.  269 : 6009

PubMed: 12473096
DOI: 10.1046/J.1432-1033.2002.03278.X

Solution Structure of Human Corticotropin Releasing Factor by 1H NMR and Distance Geometry with Restrained Molecular Dynamics.

Romier, C.,Bernassau, J.M.,Cambillau, C.  et al.
(1993)  Protein Eng.  6 : 149

PubMed: 8386360
DOI: 10.1093/PROTEIN/6.2.149

Reaction

Chain : A
UniProt : P06850 (CRF_HUMAN)
Reaction : -