Brand  (β version)

PDB ID: 1GIM

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Ligands
Code Name Style Show Link
GDP Guanosine-5'-diphosphate PoSSuM
HDA Hadacidin PoSSuM
IMP Inosinic acid PoSSuM
MG Magnesium ion PoSSuM
NO3 Nitrate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1GIM   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : CRYSTAL STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM ESCHERICHIA COLI COMPLEXED WITH GDP, IMP, HADACIDIN, NO3-, AND MG2+. DATA COLLECTED AT 100K (PH 6.5)
Release Data : 1996-12-23
Compound :
mol_id molecule chains
1 ADENYLOSUCCINATE SYNTHETASE A
ec: 6.3.4.4
Source :
mol_id organism_scientific
1 Escherichia coli  (taxid:562)
strain: PUR A STRAIN H1238
atcc: COLI GENETIC STOCK CENTER, STRAIN NUMBER 5408
other_details: GIFT FROM DR. B. BACHMAN (GENETIC CENTER, YALE UNIVERSITY)
Authors : Poland, B.W., Fromm, H.J., Honzatko, R.B.
Keywords : PURINE NUCLEOTIDE BIOSYNTHESIS, LIGASE, SYNTHETASE, GTP-HYDROLYZING ENZYMES
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Crystal structures of adenylosuccinate synthetase from Escherichia coli complexed with GDP, IMP hadacidin, NO3-, and Mg2+.

Poland, B.W.,Fromm, H.J.,Honzatko, R.B.
(1996)  J.Mol.Biol.  264 : 1013 - 1027

PubMed: 9000627
DOI: 10.1006/jmbi.1996.0693

Refined Crystal Structures of Unligated Adenylosuccinate Synthetase from E.Coli

Silva, M.M.,Poland, B.W.,Hoffman, C.R.  et al.
(1995)  J.Mol.Biol.  254 : 431

Crystal Structure of Adenylosuccinate Synthetase from E.Coli

Poland, B.W.,Silva, M.M.,Serra, M.A.  et al.
(1993)  J.Biol.Chem.  268 : 25334

Reaction

Chain : A
UniProt : P0A7D4 (PURA_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+) 6.3.4.4 HAMAP-Rule:MF_00011
-
Cofactor: Evidence: Note:
Mg(2+) - Binds 1 Mg(2+) ion per subunit.