Brand  (β version)

PDB ID: 1GG8

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Ligands
Code Name Style Show Link
IMP Inosinic acid PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
GLG Alpha-D-glucopyranosyl-2-carboxylic acid amide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1GG8   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : DESIGN OF INHIBITORS OF GLYCOGEN PHOSPHORYLASE: A STUDY OF ALPHA-AND BETA-C-GLUCOSIDES AND 1-THIO-BETA-D-GLUCOSE COMPOUNDS
Release Data : 2000-08-23
Compound :
mol_id molecule chains
1 PROTEIN (GLYCOGEN PHOSPHORYLASE) A
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
tissue: MUSCLE
Authors : Watson, K.A., Mitchell, E.P., Johnson, L.N., Son, J.C., Bichard, C.J., Orchard, M.G., Fleet, G.W., Oikonomakos, N.G., Leonidas, D.D., Kontou, M., Papageorgiou, A.C.
Keywords : GLYCOGEN PHOSPHORYLASE, INHIBITOR COMPLEX, CATALYTIC SITE, DESIGN, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.31 Å )
Citation :

Design of inhibitors of glycogen phosphorylase: a study of alpha- and beta-C-glucosides and 1-thio-beta-D-glucose compounds.

Watson, K.A.,Mitchell, E.P.,Johnson, L.N.  et al.
(1994)  Biochemistry  33 : 5745 - 5758

PubMed: 8180201
DOI: 10.1021/bi00185a011

N-Acetyl-Beta-D-Glucopyranosylamine: A Potent T-State Inhibitor of Glycogen Phosphorylase. A Comparison with Alpha-D-Glucose

Oikonomakos, N.G.,Kontou, M.,Zographos, S.E.  et al.
(1995)  Protein Sci.  4 : 2469 - 2477

Reaction

Chain : A
UniProt : P00489 (PYGM_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 UniProtKB:P11217
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