Brand  (β version)

PDB ID: 1G9T

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Ligands
Code Name Style Show Link
5GP Guanosine-5'-monophosphate PoSSuM
N Any 5'-monophosphate nucleotide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1G9T   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : CRYSTAL STRUCTURE OF E.COLI HPRT-GMP COMPLEX
Release Data : 2002-08-28
Compound :
mol_id molecule chains
1 HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE A,B
ec: 2.4.2.8
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: HPT
expression_system_strain: SPHI606
expression_system_vector_type: PLASMID
expression_system_plasmid: PT7-7
Authors : Guddat, L.W., Vos, S., Martin, J.L., keough, D.T., de Jersey, J.
Keywords : phosphoribosyltransferases, purine salvage, protein chemistry, enzymology, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.8 Å )
Citation :

Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase.

Guddat, L.W.,Vos, S.,Martin, J.L.  et al.
(2002)  Protein Sci.  11 : 1626 - 1638

PubMed: 12070315
DOI: 10.1110/ps.0201002

Reaction

Chain : A, B
UniProt : P0A9M2 (HPRT_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine 2.4.2.8 PubMed:12070315
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diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine 2.4.2.8 PubMed:12070315
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