Brand  (β version)

PDB ID: 1G2V

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Ligands
Code Name Style Show Link
TTP Thymidine-5'-triphosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1G2V   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : THE STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND REGULATION OF GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA). TTP COMPLEX.
Release Data : 2000-12-27
Compound :
mol_id molecule chains synonym
1 GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE A,B,C,D,E,F,G,H GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA)
ec: 2.7.7.24
Source :
mol_id organism_scientific expression_system
1 Pseudomonas aeruginosa  (taxid:287) Escherichia coli  (taxid:562)
expression_system_strain: BL21(LAMBDA DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET23A(+)
Authors : Blankenfeldt, W., Asuncion, M., Lam, J.S., Naismith, J.H.
Keywords : L-RHAMNOSE, NUCLEOTIDYLTRANSFERASE, PYROPHOSPHORYLASE, THYMIDYLYLTRANSFERASE, ALLOSTERY, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (RmlA).

Blankenfeldt, W.,Asuncion, M.,Lam, J.S.  et al.
(2000)  EMBO J.  19 : 6652 - 6663

PubMed: 11118200
DOI: 10.1093/emboj/19.24.6652

The Purification, Crystallisation and Preliminary Structural Characterisation of Glucose-1-Phosphate Thymidylyltransferase (Rmla), the First Enzyme of the Dtdp-L-Rhamnose Synthesis Pathway from Pseudomonas Aeruginosa

Blankenfeldt, W.,Giraud, M.F.,Leonard, G.  et al.
(2000)  Acta Crystallogr.,Sect.D  56 : 1501 - 1504

DOI: 10.1107/S0907444900010040

The Nucleotide Specificity and Feedback Control of Thymidine Diphosphate D-Glucose Pyrophosphorylase.

Melo, A.,Glaser, L.
(1965)  J.Biol.Chem.  240 : 398 - 405

Reaction

Chain : A, B, C, D, E, F, G, H
UniProt : Q9HU22 (Q9HU22_PSEAE)
Reaction: EC: Evidence:
Physiological Direction:
alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose 2.7.7.24 ARBA:ARBA00001095, RuleBase:RU003706
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