Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0G6 D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide
Code : 1FXY
Header : hydrolase/hydrolase inhibitor
Title : COAGULATION FACTOR XA-TRYPSIN CHIMERA INHIBITED WITH D-PHE-PRO-ARG-CHLOROMETHYLKETONE
Release Data : 1998-06-17
Compound :
mol_id molecule chains
1 COAGULATION FACTOR XA-TRYPSIN CHIMERA A
mutation: Q20Y, E21N, C27V
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_strain: UT5600
Authors : Hopfner, K.P., Kopetzki, E., Kresse, G.-B., Huber, R., Bode, W., Engh, R.A.
Keywords : CHIMERA, PROTEASE, CHLOROMETHYLKETONE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

New enzyme lineages by subdomain shuffling.

Hopfner, K.P.,Kopetzki, E.,Kresse, G.B.  et al.
(1998)  Proc.Natl.Acad.Sci.USA  95 : 9813 - 9818

PubMed: 9707558
DOI: 10.1073/pnas.95.17.9813

Chain : A
UniProt : P07477 (TRY1_HUMAN)
Reaction : Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.