Brand  (β version)

PDB ID: 1FWM

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Ligands
Code Name Style Show Link
CB3 10-propargyl-5,8-dideazafolic acid PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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CXM N-carboxymethionine
Glycosylation
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Structure summary

Code : 1FWM   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of the thymidylate synthase R166Q mutant
Release Data : 2003-11-11
Compound :
mol_id molecule chains
1 THYMIDYLATE SYNTHASE A,B
ec: 2.1.1.45
mutation: R166Q
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
Authors : Sotelo-Mundo, R.R., Changchien, L., Maley, F., Montfort, W.R.
Keywords : methyltransferase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Crystal structures of thymidylate synthase mutant R166Q: Structural basis for the nearly complete loss of catalytic activity.

Sotelo-Mundo, R.R.,Changchien, L.,Maley, F.  et al.
(2006)  J.Biochem.Mol.Toxicol.  20 : 88 - 92

PubMed: 16615077
DOI: 10.1002/jbt.20122

Crystallographics studied of thymidylate synthase: structure of a mammalian enzyme and analyses of invariant non-catalytic residues in a bacterial enzyme

Sotelo-Mundo, R.R.
(1999)  Thesis  : 1 - 138

Reaction

Chain : A, B
UniProt : P0A884 (TYSY_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP 2.1.1.45 HAMAP-Rule:MF_00008, PubMed:2223754, PubMed:3286637, PubMed:9826509
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