Brand  (β version)

PDB ID: 1FV0

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
ACT Acetate ion PoSSuM
9AR 9-hydroxy aristolochic acid PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1FV0   PDBj   RCSB PDB   PDBe
Header : TOXIN
Title : FIRST STRUCTURAL EVIDENCE OF THE INHIBITION OF PHOSPHOLIPASE A2 BY ARISTOLOCHIC ACID: CRYSTAL STRUCTURE OF A COMPLEX FORMED BETWEEN PHOSPHOLIPASE A2 AND ARISTOLOCHIC ACID
Release Data : 2002-08-28
Compound :
mol_id molecule chains
1 PHOSPHOLIPASE A2 A,B
Source :
mol_id organism_scientific
1 Daboia russellii pulchella  (taxid:97228)
strain: pulchella
secretion: VENOM
Authors : Chandra, V., Jasti, J., Kaur, P., Srinivasan, A., Betzel, C., Singh, T.P.
Keywords : phospholipase A2, Daboia russelli pulchella, neurotoxic, edema, TOXIN
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Structural Basis of Phospholipase A2 Inhibition for the Synthesis of Prostaglandins by the Plant Alkaloid Aristolochic Acid from a 1.7 A Crystal Structure

Chandra, V.,Jasti, J.,Kaur, P.  et al.
(2002)  Biochemistry  41 : 10914 - 10919

PubMed: 12206661
DOI: 10.1021/bi0258593

First structural evidence of antiinflammatory action of vitamin E (2,5,7,8-tetramethyl-2-(4',8',12'-trimethyltridecyl)-6-chromanol) through its binding to phospholipase A2 specifically: Crystal structure of a complex formed between phospholipase A2 and vitamin E at 1.80 resolution

Chandra, V.,Jasti, J.,Kaur, P.  et al.
To be Published 

Three-dimensional structure of a presynaptic neurotoxic phospholipase A2 from Daboia russelli pulchella at 2.4 resolution

Chandra, V.,Kaur, P.,Srinivasan, A.  et al.
(2000)  J.Mol.Biol.  296 : 1117 - 1126

DOI: 10.1006/jmbi.2000.3537

Reaction

Chain : A, B
UniProt : P59071 (PA2B8_DABRR)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+) 3.1.1.4 PubMed:16596639
-