PDB ID: 1FTQ
Hetero Atom Contents
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Color scheme of protein:
Code | Name | Style | Show | Link | |
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IMP | Inosinic acid | PoSSuM | |||
PLP | Pyridoxal-5'-phosphate | PoSSuM | |||
GL2 | (5s,7r,8s,9s,10r)-3-amino-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione | PoSSuM |
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Download interaction data: 1FTQ
Structure summary
Code : | 1FTQ PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN | ||||||||||||
Release Data : | 2000-10-04 | ||||||||||||
Compound : |
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Source : |
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Authors : | Watson, K.A., Tsitsanou, K.E., Gregoriou, M., Zographos, S.E., Skamnaki, V.T., Oikonomakos, N.G., Fleet, G.W., Johnson, L.N. | ||||||||||||
Keywords : | TRANSFERASE, GLYCOGEN PHOSPHORYLASE, INHIBITOR COMPLEX, CATALYTIC SITE, DESIGN | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.35 Å ) | ||||||||||||
Citation : |
Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.
Watson, K.A.,Chrysina, E.D.,Tsitsanou, K.E.
et al.
PubMed: 16222658 The Structure of a Glycogen Phosphorylase Glucopyranose Spirohydantoin Complex at 1.8 A Resolution and 100K: The Role of the Water Structure and its Contribution to Binding
Gregoriou, M.,Noble, M.E.,Watson, K.A.
et al.
Potent Inhibition of Glycogen Phosphorylase by a Spirohydantoin of Glucopyranose: First Pyranose Analogues of Hydantocidin
Bichard, C.J.F.,Mitchell, E.P.,Wormald, M.R.
et al.
N-Acetyl-Beta-D-Glucopyranosylamine: A Potent T-State Inhibitor of Glycogen Phosphorylase. A Comparison with Alpha-D-Glucose
Oikonomakos, N.G.,Kontou, M.,Zographos, S.E.
et al.
Design of Inhibitors of Glycogen Phosphorylase: A Study of Alpha- and Beta-C-Glucosides and 1-Thio-Beta-D-Glucose Compounds
Watson, K.A.,Mitchell, E.P.,Johnson, L.N.
et al.
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Reaction
Chain : | A | ||||||||
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UniProt : | P00489 (PYGM_RABIT) | ||||||||
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