Het-PDB Navi2 (PDB: 1FT2)

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Ligands
Code	Name		Style	Show	Link
FPP	Farnesyl diphosphate				PoSSuM
ZN	Zinc ion				PoSSuM

Non-standard Residues
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Glycosylation
Code	Name	Emphasize

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Download interaction data: 1FT2

Code :

1FT2 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

CO-CRYSTAL STRUCTURE OF PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A FARNESYL DIPHOSPHATE SUBSTRATE

Release Data :

1998-11-04

Compound :

mol_id	molecule	chains
1	PROTEIN FARNESYLTRANSFERASE	A
	ec: 2.5.1.-

mol_id	molecule	chains
2	PROTEIN FARNESYLTRANSFERASE	B
	ec: 2.5.1.-

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Rattus norvegicus (taxid:10116)	Norway rat	Spodoptera frugiperda (taxid:7108)
	organ: BRAIN cellular_location: CYTOPLASM gene: CDNA expression_system_common: Fall armyworm expression_system_cell_line: SF9 expression_system_vector_type: BACULOVIRUS expression_system_vector: PACUW51 (PHARMINGEN) expression_system_plasmid: BACULOVIRUS

mol_id	organism_scientific	organism_common	expression_system
2	Rattus norvegicus (taxid:10116)	Norway rat	Spodoptera frugiperda (taxid:7108)
	organ: BRAIN cellular_location: CYTOPLASM gene: CDNA expression_system_common: Fall armyworm expression_system_cell_line: SF9 expression_system_vector_type: BACULOVIRUS expression_system_vector: PACUW51 (PHARMINGEN) expression_system_plasmid: BACULOVIRUS

Authors :

Beese, L.S., Casey, P.J., Long, S.B.

Keywords :

PROTEIN FARNESYLTRANSFERASE, FARNESYL DIPHOSPHATE, CANCER THERAPEUTICS, PRENYLTRANSFERASE, ISOPRENOID, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 3.40 Å )

Citation :

Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.

Long, S.B.,Casey, P.J.,Beese, L.S.
(1998) Biochemistry 37 : 9612 - 9618

PubMed: 9657673
DOI: 10.1021/bi980708e

Crystal Structure of Protein Farnesyltransferase at 2.25 Angstrom Resolution

Park, H.W.,Boduluri, S.R.,Moomaw, J.F. et al.
(1997) Science 275 : 1800

Erratum. Crystal Structure of Protein Farnesyltransferase at 2.25 Angstrom Resolution

Park, H.W.,Boduluri, S.R.,Moomaw, J.F. et al.
(1997) Science 276 : 21

High Level Expression of Mammalian Protein Farnesyltransferase in a Baculovirus System. The Purified Protein Contains Zinc

Chen, W.J.,Moomaw, J.F.,Overton, L. et al.
(1993) J.Biol.Chem. 268 : 9675

Chain :

UniProt :

Q04631 (FNTA_RAT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]	2.5.1.58	PubMed:12657282, PubMed:18844669, PubMed:19219049, PubMed:22963166
	-
geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]	2.5.1.59	PubMed:14609943, PubMed:19219049
	-	PubMed:14609943, PubMed:19219049

Chain :

UniProt :

Q02293 (FNTB_RAT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]	2.5.1.58	PubMed:10673434, PubMed:18844669, PubMed:19219049, PubMed:19246009, PubMed:22963166
	-

PDB ID: 1FT2

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