Het-PDB Navi2 (PDB: 1FSW)

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Ligands
Code	Name		Style	Show	Link
CTB	N-2-thiophen-2-yl-acetamide boronic acid				PoSSuM
PO4	Phosphate ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1FSW

Code :

1FSW PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

AMPC BETA-LACTAMASE FROM E. COLI COMPLEXED WITH INHIBITOR CEPHALOTHINBORONIC ACID

Release Data :

2001-03-14

Compound :

mol_id	molecule	chains	synonym
1	CEPHALOSPORINASE	A,B	BETA-LACTAMASE
	ec: 3.5.2.6 other_details: SER 64 BINDS TO BORON OF LIGAND CTB IN BOTH CHAINS

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:83333)	Escherichia coli (taxid:562)
	strain: K12 expression_system_vector_type: PLASMID expression_system_plasmid: POGO295

Authors :

Caselli, E., Powers, R.A., Blaszczak, L.C., Wu, C.Y., Prati, F., Shoichet, B.K.

Keywords :

cephalosporinase, beta-lactamase, serine hydrolase, hydrolase

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases.

Caselli, E.,Powers, R.A.,Blasczcak, L.C. et al.
(2001) Chem.Biol. 8 : 17 - 31

Chain :

A, B

UniProt :

P00811 (AMPC_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	PROSITE-ProRule:PRU10102, PubMed:12323371, PubMed:3264154, PubMed:3264155, PubMed:6998377
a beta-lactam + H2O = a substituted beta-amino acid	-

PDB ID: 1FSW