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Ligands
Code Name Style Show Link
9DG 9-deazaguanine
MG Magnesium ion
PRP 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose
Non-standard Residues
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Glycosylation
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Code : 1FSG   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : TOXOPLASMA GONDII HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH 9-DEAZAGUANINE, ALPHA-D-5-PHOSPHORIBOSYL-1-PYROPHOSPHATE (PRPP) AND TWO MG2+ IONS
Release Data : 2000-12-06
Compound :
mol_id molecule chains synonym
1 HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE A,C HGPRTASE
ec: 2.4.2.8
Source :
mol_id organism_scientific expression_system
1 Toxoplasma gondii  (taxid:383379) Escherichia coli BL21(DE3)  (taxid:469008)
strain: RH
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_vector: PET15B
expression_system_plasmid: PETC1
Authors : Heroux, A., White, E.L., Ross, L.J., Kuzin, A.P., Borhani, D.W.
Keywords : GLYCOSYLTRANSFERASE, PURINE SALVAGE, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.05 Å )
Citation :

Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: the structural basis for catalysis.

Heroux, A.,White, E.L.,Ross, L.J.  et al.
(2000)  Structure Fold.Des.  8 : 1309 - 1318

PubMed: 11188695
DOI: 10.1016/S0969-2126(00)00546-3

Crystal Structures of the Toxoplasma Gondii Hypoxanthine-Guanine Phosphoribosyltransferase-GMP and -IMP Complexes:Comparison of purine binding Interactions with the XMP Complex

Heroux, A.,White, E.L.,Ross, L.J.  et al.
(1999)  Biochemistry  38 : 14485 - 14494

DOI: 10.1021/bi990507q

Crystal Structure of Toxoplasma Gondii Hypoxanthine-Guanine Phosphoribosyltransferase with XMP, Pyrophosphate, and Two Mg(2+) Ions Bound:Insights into the Catalytic Mechanism

Heroux, A.,White, E.L.,Ross, L.J.  et al.
(1999)  Biochemistry  38 : 14495 - 14506

DOI: 10.1021/bi990508i

Isolation and Sequencing of a Cdna Encoding the Hypoxanthine-Guanine Phosphoribosyltransferase from Toxoplasma Gondii

Vasanthakumar, G.,van Ginkel, S.,Parish, G.
(1994)  Gene  147 : 153 - 154

DOI: 10.1016/0378-1119(94)90058-2

Chain : A, C
UniProt : Q26997 (HGXR_TOXGO)
Reaction: EC: Evidence:
Physiological Direction:
diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine 2.4.2.8 PubMed:10545171, PubMed:11188695
right-to-left
diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine 2.4.2.8 PubMed:10545171, PubMed:11188695
right-to-left
diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine 2.4.2.22 PubMed:10545171, PubMed:11188695
right-to-left