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Ligands
Code Name Style Show Link
PLP Pyridoxal-5'-phosphate
CRA 1-deoxy-1-methoxycarbamido-beta-D-gluco-2-heptulopyranosonamide
Non-standard Residues
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Glycosylation
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Code : 1FS4   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structures of glycogen phosphorylase-inhibitor complexes and the implications for structure-based drug design
Release Data : 2000-10-04
Compound :
mol_id molecule chains
1 GLYCOGEN PHOSPHORYLASE A
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
tissue: MUSCLE
Authors : Watson, K.A., Tsitsanou, K.E., Gregoriou, M., Zographos, S.E., Skamnaki, V.T., Oikonomakos, N.G., Fleet, G.W., Johnson, L.N.
Keywords : enzyme-inhibitor complex, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.38 Å )
Citation :

Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.

Watson, K.A.,Chrysina, E.D.,Tsitsanou, K.E.  et al.
(2005)  Proteins  61 : 966 - 983

PubMed: 16222658
DOI: 10.1002/prot.20653

The Structure of a Glycogen Phosphorylase Glucopyranose Spirohydantoin Complex at 1.8 A Resolution and 100K: The Role of the Water Structure and its Contribution to Binding

Gregoriou, M.,Noble, M.E.,Watson, K.A.  et al.
(1998)  Protein Sci.  7 : 915 - 927

Potent Inhibition of Glycogen Phosphorylase by a Spirohydantoin of Glucopyranose: First Pyranose Analogues of Hydantocidin

Bichard, C.J.F.,Mitchell, E.P.,Wormald, M.R.  et al.
(1995)  Tetrahedron Lett.  36 : 2145 - 2148

DOI: 10.1016/0040-4039(95)00197-K

N-Acetyl-Beta-D-Glucopyranosylamine: A Potent T-State Inhibitor of Glycogen Phosphorylase. A Comparison with Alpha-D-Glucose

Oikonomakos, N.G.,Kontou, M.,Zographos, S.E.  et al.
(1995)  Protein Sci.  4 : 2469 - 2477

Design of Inhibitors of Glycogen Phosphorylase: A Study of Alpha- and Beta-C-Glucosides and 1-Thio-Beta-D-Glucose Compounds

Watson, K.A.,Mitchell, E.P.,Johnson, L.N.  et al.
(1994)  Biochemistry  33 : 5745 - 5758

Chain : A
UniProt : P00489 (PYGM_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 UniProtKB:P11217
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