Brand  (β version)

PDB ID: 1FQK

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
ALF Tetrafluoroaluminate ion PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1FQK   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]
Release Data : 2001-02-28
Compound :
mol_id molecule chains synonym
1 Guanine nucleotide-binding protein G(t) subunit alpha-1,Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(t) subunit alpha-1 A,C Transducin alpha-1 chain,Adenylate cyclase-inhibiting G alpha protein,Transducin alpha-1 chain
fragment: UNP P04695 residues 26-215 and 295-350 linked via UNP P10824 residues 220-298
other_details: THE CHIMERA COMPRISES RESIDUES 26 TO 215 OF BOVINE GT, RESIDUES 220 TO 298 OF RAT GI1, AND RESIDUES 295 TO 350 OF BOVINE GT
mol_id molecule chains synonym
2 Regulator of G-protein signaling 9 B,D RGS9
fragment: RGS DOMAIN, UNP RESIDUES 276-422
Source :
mol_id organism_scientific organism_common expression_system
1 Bos taurus  (taxid:9913) Bovine Escherichia coli  (taxid:562)
gene: GNAT1
expression_system_vector_type: PLASMID
expression_system_plasmid: PHIS6(T7)
mol_id organism_scientific organism_common expression_system
2 Bos taurus  (taxid:9913) Bovine Escherichia coli  (taxid:562)
gene: RGS9
expression_system_vector_type: PLASMID
expression_system_plasmid: PGEX-2T
Authors : Slep, K.C., Kercher, M.A., He, W., Cowan, C.W., Wensel, T.G., Sigler, P.B.
Keywords : RGS9, transducin, G Protein, Phototransduction, rod, RGS, GAP, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A.

Slep, K.C.,Kercher, M.A.,He, W.  et al.
(2001)  Nature  409 : 1071 - 1077

PubMed: 11234020
DOI: 10.1038/35059138

Reaction

Chain : A, C
UniProt : P04695 (GNAT1_BOVIN)
Reaction : -
Chain : A, C
UniProt : P10824 (GNAI1_RAT)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) - UniProtKB:P63096
left-to-right
Chain : B, D
UniProt : O46469 (RGS9_BOVIN)
Reaction : -