Brand  (β version)

PDB ID: 1FPP

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Ligands
Code Name Style Show Link
FPP Farnesyl diphosphate PoSSuM
PO4 Phosphate ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1FPP   PDBj   RCSB PDB   PDBe
Header : PRENYLTRANSFERASE
Title : PROTEIN FARNESYLTRANSFERASE COMPLEX WITH FARNESYL DIPHOSPHATE
Release Data : 1999-06-08
Compound :
mol_id molecule chains synonym
1 PROTEIN FARNESYLTRANSFERASE B FTASE
ec: 2.5.1.-
other_details: PURIFIED RECOMBINANT FTASE WAS TREATED WITH PROTEASE GLUC PRIOR TO CRYSTALLIZATION
mol_id molecule chains synonym
2 PROTEIN FARNESYLTRANSFERASE A FTASE
ec: 2.5.1.-
other_details: PURIFIED RECOMBINANT FTASE WAS TREATED WITH PROTEASE GLUC PRIOR TO CRYSTALLIZATION
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Trichoplusia ni  (taxid:7111)
gene: FNTA, FNTB
expression_system_common: Cabbage looper
expression_system_cell_line: HIGH FIVE (INVITROGEN)
expression_system_vector_type: BACULOVIRUS
expression_system_vector: PVL1393
other_details: VIRAL EXPRESSION CONSTRUCTS WERE PROVIDED BY M. S. BROWN AND J. L. GOLDSTEIN (SOUTHWESTERN MEDICAL CENTER, DALLAS, TX)
mol_id organism_scientific organism_common expression_system
2 Rattus norvegicus  (taxid:10116) Norway rat Trichoplusia ni  (taxid:7111)
gene: FNTA, FNTB
expression_system_common: Cabbage looper
expression_system_cell_line: HIGH FIVE (INVITROGEN)
expression_system_vector_type: BACULOVIRUS
expression_system_vector: PVL1393
other_details: VIRAL EXPRESSION CONSTRUCTS WERE PROVIDED BY M. S. BROWN AND J. L. GOLDSTEIN (SOUTHWESTERN MEDICAL CENTER, DALLAS, TX)
Authors : Dunten, P., Kammlott, U., Crowther, R., Weber, D., Palermo, R., Birktoft, J.
Keywords : PRENYLTRANSFERASE, MEMBRANE LOCALIZATION, HETERODIMER, ZINC
Exp. method : X-RAY DIFFRACTION ( 2.75 Å )
Citation :

Protein farnesyltransferase: structure and implications for substrate binding.

Dunten, P.,Kammlott, U.,Crowther, R.  et al.
(1998)  Biochemistry  37 : 7907 - 7912

PubMed: 9609683
DOI: 10.1021/bi980531o

Reaction

Chain : B
UniProt : Q02293 (FNTB_RAT)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:10673434, PubMed:18844669, PubMed:19219049, PubMed:19246009, PubMed:22963166
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Chain : A
UniProt : Q04631 (FNTA_RAT)
Reaction: EC: Evidence:
Physiological Direction:
(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein] 2.5.1.58 PubMed:12657282, PubMed:18844669, PubMed:19219049, PubMed:22963166
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geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein] 2.5.1.59 PubMed:14609943, PubMed:19219049
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