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Ligands
Code Name Style Show Link
AMP Adenosine monophosphate
TL Thallium (I) ion
AHG 2,5-anhydro-1,6-di-O-phosphono-D-glucitol
Non-standard Residues
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Glycosylation
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Code : 1FPJ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE (PHOSPHORIC MONOESTER)
Title : FRUCTOSE-1,6-BISPHOSPHATASE (D-FRUCTOSE-1,6-BISPHOSPHATE 1-PHOSPHOHYDROLASE) COMPLEXED WITH AMP, 2,5-ANHYDRO-D-GLUCITOL-1,6-BISPHOSPHATE, THALLIUM (10 MM) AND LITHIUM IONS (10 MM)
Release Data : 1996-06-20
Compound :
mol_id molecule chains synonym
1 FRUCTOSE-1,6-BISPHOSPHATASE A,B D-FRUCTOSE-1,6-BISPHOSPHATE 1-PHOSPHOHYDROLASE
ec: 3.1.3.11
Source :
mol_id organism_scientific organism_common
1 Sus scrofa  (taxid:9823) Pig
organ: KIDNEY
Authors : Villeret, V., Lipscomb, W.N.
Keywords : HYDROLASE, PHOSPHORIC MONOESTER, CARBOHYDRATE METABOLISM, HYDROLASE (PHOSPHORIC MONOESTER)
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

Crystallographic evidence for the action of potassium, thallium, and lithium ions on fructose-1,6-bisphosphatase.

Villeret, V.,Huang, S.,Fromm, H.J.  et al.
(1995)  Proc.Natl.Acad.Sci.USA  92 : 8916 - 8920

PubMed: 7568043
DOI: 10.1073/pnas.92.19.8916

Structural Aspects of the Allosteric Inhibition of Fructose-1,6-Bisphosphatase by AMP: The Binding of Both the Substrate Analogue 2,5-Anhydro-D-Glucitol 1,6-Bisphosphate and Catalytic Metal Ions Monitored by X-Ray Crystallography

Villeret, V.,Huang, S.,Zhang, Y.  et al.
(1995)  Biochemistry  34 : 4307

Structural Similarities between Fructose-1,6-Bisphosphatase and Inositol Monophosphatase

Zhang, Y.,Liang, J.Y.,Lipscomb, W.N.
(1993)  Biochem.Biophys.Res.Commun.  190 : 1080

Crystallographic Studies of the Catalytic Mechanism of the Neutral Form of Fructose-1,6-Bisphosphatase

Zhang, Y.,Liang, J.Y.,Huang, S.  et al.
(1993)  Biochemistry  32 : 1844

Chain : A, B
UniProt : P00636 (F16P1_PIG)
Reaction: EC: Evidence:
Physiological Direction:
beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate 3.1.3.11 PubMed:15767255, PubMed:1313579
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