Brand  (β version)

color scheme of protein:

chain: Hide other chain(s)

Modified Residues
Code Name Link
0QE Chloromethane
ACE Acetyl group
AR7 Amino{[(4s)-4-amino-5,5-dihydroxypentyl]amino}methaniminium
Code : 1FPH
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : THE INTERACTION OF THROMBIN WITH FIBRINOGEN: A STRUCTURAL BASIS FOR ITS SPECIFICITY
Release Data : 1994-01-31
Compound :
mol_id molecule chains
1 ALPHA-THROMBIN (SMALL SUBUNIT) L
ec: 3.4.21.5
mol_id molecule chains
2 ALPHA-THROMBIN (LARGE SUBUNIT) H
ec: 3.4.21.5
mol_id molecule chains
3 HIRUDIN I
mol_id molecule chains
4 FIBRINOPEPTIDE A F
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific
3 Hirudo medicinalis  (taxid:6421)
synthetic: yes
mol_id organism_scientific
4
synthetic: yes
Authors : Stubbs, M.T., Bode, W.
Keywords : HYDROLASE, SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

The interaction of thrombin with fibrinogen. A structural basis for its specificity.

Stubbs, M.T.,Oschkinat, H.,Mayr, I.  et al.
(1992)  Eur.J.Biochem.  206 : 187 - 195

PubMed: 1587268
DOI: 10.1111/j.1432-1033.1992.tb16916.x

A Player of Many Parts: The Spotlight Falls on Thrombin'S Structure

Stubbs, M.T.,Bode, W.
(1993)  Thromb.Res.  69 : 1

The Refined 1.9 Angstroms X-Ray Crystal Structure of D-Phe-Pro-Arg Chloromethylketone-Inhibited Human Alpha-Thrombin: Structure Analysis, Overall Structure, Electrostatic Properties, Detailed Active-Site Geometry, and Structure-Function Relationships

Bode, W.,Turk, D.,Karshikov, A.
(1992)  Protein Sci.  1 : 426

Refined Structure of the Hirudin-Thrombin Complex

Rydel, T.J.,Tulinsky, A.,Bode, W.  et al.
(1991)  J.Mol.Biol.  221 : 583

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction : Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.