Het-PDB Navi2 (PDB: 1FPH)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
AR7	Amino{[(4s)-4-amino-5,5-dihydroxypentyl]amino}methaniminium

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
0QE	Chloromethane
ACE	Acetyl group

Download interaction data: 1FPH

Code :

1FPH PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

THE INTERACTION OF THROMBIN WITH FIBRINOGEN: A STRUCTURAL BASIS FOR ITS SPECIFICITY

Release Data :

1994-01-31

Compound :

mol_id	molecule	chains
1	ALPHA-THROMBIN (SMALL SUBUNIT)	L
	ec: 3.4.21.5

mol_id	molecule	chains
2	ALPHA-THROMBIN (LARGE SUBUNIT)	H
	ec: 3.4.21.5

mol_id	molecule	chains
3	HIRUDIN	I

mol_id	molecule	chains
4	FIBRINOPEPTIDE A	F

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific
3	Hirudo medicinalis (taxid:6421)
	synthetic: yes

mol_id	organism_scientific
4
	synthetic: yes

Authors :

Stubbs, M.T., Bode, W.

Keywords :

HYDROLASE, SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.5 Å )

Citation :

The interaction of thrombin with fibrinogen. A structural basis for its specificity.

Stubbs, M.T.,Oschkinat, H.,Mayr, I. et al.
(1992) Eur.J.Biochem. 206 : 187 - 195

PubMed: 1587268
DOI: 10.1111/j.1432-1033.1992.tb16916.x

A Player of Many Parts: The Spotlight Falls on Thrombin'S Structure

Stubbs, M.T.,Bode, W.
(1993) Thromb.Res. 69 : 1

The Refined 1.9 Angstroms X-Ray Crystal Structure of D-Phe-Pro-Arg Chloromethylketone-Inhibited Human Alpha-Thrombin: Structure Analysis, Overall Structure, Electrostatic Properties, Detailed Active-Site Geometry, and Structure-Function Relationships

Bode, W.,Turk, D.,Karshikov, A.
(1992) Protein Sci. 1 : 426

Refined Structure of the Hirudin-Thrombin Complex

Rydel, T.J.,Tulinsky, A.,Bode, W. et al.
(1991) J.Mol.Biol. 221 : 583

Chain :

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

PDB ID: 1FPH

Hetero Atom Contents

Structure summary

Reaction