Brand  (β version)

PDB ID: 1FPC

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Ligands
Code Name Style Show Link
0ZI Amino{[(4s)-4-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)-5-(4-ethylpiperidin-1-yl)-5-oxopentyl]amino}methaniminium PoSSuM
Non-standard Residues
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TYS O-sulfo-L-tyrosine
Glycosylation
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Structure summary

Code : 1FPC   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : ACTIVE SITE MIMETIC INHIBITION OF THROMBIN
Release Data : 1995-02-27
Compound :
mol_id molecule chains synonym
1 thrombin L Coagulation factor II
ec: 3.4.21.5
mol_id molecule chains synonym
2 thrombin H Coagulation factor II
ec: 3.4.21.5
mol_id molecule chains
3 Hirudin I
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
organ: BLOOD
tissue: BLOOD
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
organ: BLOOD
tissue: BLOOD
mol_id organism_scientific organism_common
3 Hirudo medicinalis  (taxid:6421) Medicinal leech
Authors : Tulinsky, A., Mathews, I.I.
Keywords : SERINE PROTEASE-INHIBITOR complex, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

Active-site mimetic inhibition of thrombin.

Mathews, I.I.,Tulinsky, A.
(1995)  Acta Crystallogr.,Sect.D  51 : 550 - 559

PubMed: 15299843
DOI: 10.1107/S0907444994013132

The Structure of a Designed Peptidomimetic Inhibitor Complex of Alpha-Thrombin

Wu, T.-P.,Yee, V.,Tulinsky, A.  et al.
(1993)  Protein Eng.  6 : 471

Active Site and Exosite Binding of Alpha-Thrombin

Tulinsky, A.,Qiu, X.
(1993)  Blood Coagulation Fibrinolysis  4 : 305

Interactions of a Fluorescent Active-Site-Directed Inhibitor of Thrombin: Dansylarginine N-(3-Ethyl-1,5-Pentanediyl)Amide

Nesheim, M.E.,Prendergast, F.G.,Mann, K.G.
(1979)  Biochemistry  18 : 996

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : I
UniProt : P28504 (HIR2_HIRME)
Reaction : -