Het-PDB Navi2 (PDB: 1FMO)

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Ligands
Code	Name		Style	Show	Link
ADN	Adenosine				PoSSuM

Non-standard Residues
Code	Name	Show
SEP	Phosphoserine
TPO	Phosphothreonine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1FMO

Code :

1FMO PDBj RCSB PDB PDBe

Header :

COMPLEX (PHOSPHOTRANSFERASE/INHIBITOR)

Title :

CRYSTAL STRUCTURE OF A POLYHISTIDINE-TAGGED RECOMBINANT CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH THE PEPTIDE INHIBITOR PKI(5-24) AND ADENOSINE

Release Data :

1998-01-14

Compound :

mol_id	molecule	chains	synonym
1	CAMP-DEPENDENT PROTEIN KINASE	E	CAPK, PKA
	ec: 2.7.1.37 fragment: CATALYTIC SUBUNIT

mol_id	molecule	chains	synonym
2	HEAT STABLE RABBIT SKELETAL MUSCLE INHIBITOR PROTEIN	I	PKI-ALPHA, PKI(5-24)
	fragment: RESIDUES 5 - 24

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	House mouse	Escherichia coli (taxid:562)
	organ: SKELETAL

mol_id	organism_scientific
2

Authors :

Narayana, N., Cox, S., Shaltiel, S., Taylor, S.S., Xuong, N.-H.

Keywords :

COMPLEX (PHOSPHOTRANSFERASE-INHIBITOR), PHOSPHORYLATION, POLYHISTIDINE-TAG, PROTEIN KINASE, COMPLEX (PHOSPHOTRANSFERASE-INHIBITOR) complex

Exp. method :

X-RAY DIFFRACTION ( 2.2 Å )

Citation :

Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine.

Narayana, N.,Cox, S.,Shaltiel, S. et al.
(1997) Biochemistry 36 : 4438 - 4448

PubMed: 9109651
DOI: 10.1021/bi961947+

A Binary Complex of the Catalytic Subunit of Camp-Dependent Protein Kinase and Adenosine Further Defines Conformational Flexibility

Narayana, N.,Cox, S.,Xuong, N.H. et al.
(1997) Structure 5 : 921

Crystal Structure of the Catalytic Subunit of Camp-Dependent Protein Kinase Complexed with Mgatp and Peptide Inhibitor

Zheng, J.,Knighton, D.R.,Ten Eyck, L.F. et al.
(1993) Biochemistry 32 : 2154

Expression of the Catalytic Subunit of Camp-Dependent Protein Kinase in Escherichia Coli: Multiple Isozymes Reflect Different Phosphorylation States

Herberg, F.W.,Bell, S.M.,Taylor, S.S.
(1993) Protein Eng. 6 : 771

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

Knighton, D.R.,Zheng, J.H.,Ten Eyck, L.F. et al.
(1991) Science 253 : 407

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

Knighton, D.R.,Zheng, J.H.,Ten Eyck, L.F. et al.
(1991) Science 253 : 414

Chain :

UniProt :

P05132 (KAPCA_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.11	PubMed:10805756, PubMed:19223768
	-	PubMed:10805756, PubMed:19223768
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.11	PubMed:10805756, PubMed:19223768
	-	PubMed:10805756, PubMed:19223768

Chain :	I
UniProt :	P61926 (IPKA_RABIT)
Reaction :	-

PDB ID: 1FMO

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Structure summary

Reaction