Brand  (β version)

PDB ID: 1FM9

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Ligands
Code Name Style Show Link
570 2-(2-benzoyl-phenylamino)-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-propionic acid PoSSuM
9CR (9cis)-retinoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1FM9   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND GI262570 AND CO-ACTIVATOR PEPTIDES.
Release Data : 2001-02-16
Compound :
mol_id molecule chains
1 RETINOIC ACID RECEPTOR RXR-ALPHA A
fragment: LIGAND BINDING DOMAIN - RESIDUES 225 - 462
mol_id molecule chains
2 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA D
fragment: LIGAND BINDING DOMAIN - RESIDUES 206 - 477
mol_id molecule chains
3 STEROID RECEPTOR COACTIVATOR B,E
fragment: SRC-1 PEPTIDE
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector: PLASMID
expression_system_plasmid: PACYC184
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector: PLASMID
expression_system_plasmid: PRSET
mol_id organism_scientific
3
synthetic: yes
other_details: Chemically synthesized 25mer portion of human src-1 coactivator peptide
Authors : Gampe Jr., R.T., Montana, V.G., Lambert, M.H., Miller, A.B., Bledsoe, R.K., Milburn, M.V., Kliewer, S.A., Willson, T.M., Xu, H.E.
Keywords : the heterodimer of the nuclear receptor ligand binding domains of RXRalpha and PPARgamma bound respectively with 9-cis Retinoic Acid and GI262570 and co-activator peptides, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.

Gampe Jr., R.T.,Montana, V.G.,Lambert, M.H.  et al.
(2000)  Mol.Cell  5 : 545 - 555

PubMed: 10882139
DOI: 10.1016/S1097-2765(00)80448-7

Reaction

Chain : A
UniProt : P19793 (RXRA_HUMAN)
Reaction : -
Chain : D
UniProt : P37231 (PPARG_HUMAN)
Reaction : -
Chain : B, E
UniProt : O43793 (NCOA1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] 2.3.1.48 -
-