Het-PDB Navi2 (PDB: 1FKJ)

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Ligands
Code	Name		Style	Show	Link
FK5	8-deethyl-8-[but-3-enyl]-ascomycin				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1FKJ

Code :

1FKJ PDBj RCSB PDB PDBe

Header :

ROTAMASE

Title :

ATOMIC STRUCTURE OF FKBP12-FK506, AN IMMUNOPHILIN IMMUNOSUPPRESSANT COMPLEX

Release Data :

1995-12-07

Compound :

mol_id	molecule	chains	synonym
1	FK506 BINDING PROTEIN	A	FKBP12
	ec: 5.2.1.8 other_details: MR 12,000 DALTONS

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)

Authors :

Wilson, K.P., Sintchak, M.D., Thomson, J.A., Navia, M.A.

Keywords :

FK506 BINDING PROTEIN, FKBP12, CIS-TRANS PROLYL-ISOMERASE, ROTAMASE

Exp. method :

X-RAY DIFFRACTION ( 1.7 Å )

Citation :

Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin.

Wilson, K.P.,Yamashita, M.M.,Sintchak, M.D. et al.
(1995) Acta Crystallogr.,Sect.D 51 : 511 - 521

PubMed: 15299838
DOI: 10.1107/S0907444994014514

X-Ray Structure of Calcineurin Inhibited by the Immunophilin-Immunosuppressant Fkbp12-Fk506 Complex

Griffith, J.P.,Kim, J.L.,Kim, E.E. et al.
(1995) Cell(Cambridge,Mass.) 82 : 507

Improved Calcineurin Inhibition by Yeast Fkbp12-Drug Complexes. Crystallographic and Functional Analysis

Rotonda, J.,Burbaum, J.J.,Chan, H.K. et al.
(1993) J.Biol.Chem. 268 : 7607

Fk-506-Binding Protein: Three-Dimensional Structure of the Complex with the Antagonist L-685,818

Becker, J.W.,Rotonda, J.,Mckeever, B.M. et al.
(1993) J.Mol.Biol. 268 : 11335

Atomic Structures of Human Immunophilin Fkbp-12 Complexes with Fk506 and Rapamycin

Van Duyne, G.D.,Standaert, R.F.,Karplus, P.A. et al.
(1993) J.Mol.Biol. 229 : 105

Atomic Structure of the Rapamycin Human Immunophilin Fkbp-12 Complex

Van Duyne, G.D.,Standaert, R.F.,Schreiber, S.L. et al.
(1991) J.Am.Chem.Soc. 113 : 7433

Atomic Structure of Fkbp-Fk506, an Immunophilin-Immunosuppressant Complex

Van Duyne, G.D.,Standaert, R.F.,Karplus, P.A. et al.
(1991) Science 252 : 839

Chain :

UniProt :

P62942 (FKB1A_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0)	5.2.1.8	PubMed:1696686, PubMed:1701173
	-	PubMed:1696686, PubMed:1701173

PDB ID: 1FKJ

Hetero Atom Contents

Structure summary

Reaction