Brand  (β version)

PDB ID: 1FJ8

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Ligands
Code Name Style Show Link
CER (2s, 3r)-3-hydroxy-4-oxo-7,10-trans,trans-dodecadienamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1FJ8   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH CERULENIN, IMPLICATIONS FOR DRUG DESIGN
Release Data : 2000-08-23
Compound :
mol_id molecule chains
1 BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I A,B,C,D
ec: 2.3.1.41
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_plasmid: PET15B
Authors : Price, A.C., Choi, K., Heath, R.J., Li, Z., White, S.W., Rock, C.O.
Keywords : CONDENSING ENZYMES, FATTY ACID ELONGATION, CERULENIN, DRUG DESIGN, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.27 Å )
Citation :

Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism.

Price, A.C.,Choi, K.H.,Heath, R.J.  et al.
(2001)  J.Biol.Chem.  276 : 6551 - 6559

PubMed: 11050088
DOI: 10.1074/jbc.M007101200

Reaction

Chain : A, B, C, D
UniProt : P0A953 (FABB_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP] 2.3.1.41 PubMed:19679654, PubMed:22017312, PubMed:8910376, PubMed:9013860
left-to-right PubMed:19679654, PubMed:22017312, PubMed:8910376, PubMed:9013860
(3Z)-decenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(5Z)- dodecenoyl-[ACP] + CO2 + holo-[ACP] - PubMed:19679654
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H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP] - PubMed:9013860
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H(+) + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP] - PubMed:9013860
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decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP] - PubMed:9013860
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dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl- [ACP] + CO2 + holo-[ACP] - PubMed:22017312, PubMed:9013860
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H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] = 3- oxohexadecanoyl-[ACP] + CO2 + holo-[ACP] - PubMed:8910376
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(7Z)-tetradecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(9Z)- hexadecenoyl-[ACP] + CO2 + holo-[ACP] - PubMed:8910376
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